期刊文献+

抗生育活性天然产物研究进展 被引量:2

Research on the anti-fertility activity of natural products
下载PDF
导出
摘要 天然产物是生物活性物质的重要来源,能为新药研究提供先导化合物。近年来从天然产物中寻找具有高效、选择性好的抗生育活性物质是计划生育药物研究的热点之一。本文就天然产物中的萜类、生物碱类、黄酮类化合物抗生育活性研究做一综述。 Objective Natural products had been demonstrated with significant and extremely potent biological activities,which could provide useful leading compounds for new drug research.In recent years,it was one of the hotspots for the family planning drug research to discovery the high efficiency and good selectivity anti-fertility substance from natural products.The outline of natural product anti-fertility research was summarized concisely and the emphasis was focused on the terpenoids,alkaloids and flavonoids.
出处 《药学实践杂志》 CAS 2011年第4期251-255,共5页 Journal of Pharmaceutical Practice
基金 江苏省科技支撑计划(SBE201077188)
关键词 抗生育 萜类 生物碱 黄酮 anti-fertility terpenoids alkaloids flavonoids
  • 相关文献

参考文献4

二级参考文献18

  • 1Waites G M, Wang C. Gossypol:reasons for its failure to be accepted as a safe reversible male antifertiflity drug [ J ]. Int J And, 1998, 21(Ⅰ):8-12. 被引量:1
  • 2Zhang M C, Liu H P, Tian Z K, et al. Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways [ J ]. Life Sci, 2007, 80:767 - 74. 被引量:1
  • 3Ergun U, Yurtcu E, Ergun M A. Protective effect of ginkgobitoba against gossypol-induced apoptosis in human lymphocytes [ J ]. Cell Biol lnt,2005 ,29( 8 ) :717 -20. 被引量:1
  • 4Hwang S T,Kim W J,Wee J J,et al. Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin[ J]. BJU Int,2004,94,663 -8. 被引量:1
  • 5Sheih-sher P U,Liu Y, Fai Y Y, et al. The pharmaeokinetics of 14C-gossypol acetic acid in rats Ⅱ quantitative studies on the kinetics of the distribution excretion and metabolism of 14C-gossypol acetic acid in the rat body[ C]//Studies on Cell Proliferation Differentiation and Their Regulation. Cultural China Publication Co. Ltd. HongKong,2007:220 - 31. 被引量:1
  • 6Vaienti S, Cuttia C M, Fazzuoli L, et al. Biphasic effect of nitric oxide on testosterone and cyclic GMP production by purified rat Leydig cells culture in vitro [ J ]. Int J A ndrol, 1999,22 (5) :336 - 41. 被引量:1
  • 7Adams M L,Meyer E R,Cicero T J. Effects of nitric oxide-related agents on opioid regulation of rat testicular steroidogenesis[ J]. Biol Reprod, 1996,54 ( 5 ) : 1128 - 34. 被引量:1
  • 8冷颖,杨纫姝.钙调素拮抗剂对离体培养人蜕膜细胞形态和活力的影响[J].生殖与避孕,1997,17(2):76-81. 被引量:12
  • 9Schatz F, Papp C, Aigner S et al. Biological mechanisms underlying the clinical effects of Ru486: modulation of cultured endometrial stromal cell stromelysin-1 and prolactin expression. J Clin Endocrinol Metab, 1997; 82(1):188. 被引量:1
  • 10Olivares EG,Montes MJ,Oliver C et al. Cultured human decidual stromal cells express B7-1 (CD80)and B7-2, (CD86 and stimulate allogeneic T cells. Biol Reprod, 1997 ; 57 ( 3 ) : 609. 被引量:1

共引文献19

同被引文献35

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部