摘要
目的探讨Twist、VEGF蛋白在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法应用免疫组织化学方法检测54例NSCLC标本组织、10例正常肺组织和10例肺良性病变中Twist、VEGF的表达。结果 Twist在NSCLC癌组织中的表达(68.52%)明显高于正常肺组织(10%)和肺良性病变组织(20%)(P<0.05);VEGF表达率64.8%(35/54),明显高于正常肺组织(10%)和肺良性病变(20%)(P<0.05);Twist、VEGF在NSCLC癌组织中表达与肿瘤的分化程度、临床分期及淋巴结转移有关;Twist的表达与VEGF的表达存在明显正相关(r=0.654,P=0.000)。结论 Twist蛋白可能通过VEGF介导的肿瘤血管生成,在NSCLC的浸润、转移过程中发挥重要作用。Twist具有较好的临床病理学诊断应用和治疗价值。
Objective To investigate the expression and clinical significance of Twist and VEGF in non-small-cell lung cancer（NSCLC） tissues.Methods The expression of Twist and VEGF in 54 cases of NSCLC tissues,10 cases of normal lung tissues and10 of cases benign lesion of lung was detected by using immunohistochemistry.Results The positive rates of Twist in NSCLC（68.52%） was higher than that in normal lung tissues（10%） and benign lesion of lung（20%）（P0.05）.The positive rates of VEGF in NSCLC（64.8%） was higher than that in normal lung tissues（10%） and benign lesion of lung（20%）（P0.05）.The difference of Twist and VEGF expression was significant in group of tumor differentiation,clinical stage and lymphatic metastasis（P0.05）.Positive correlation was obtained between the expression of Twist and VEGF proteins（r=0.654,P =0.000）.Conclusion Twist protein in NSCLC might play an important role in the invasiveness and metastasis of the tumor through angiogenesis via VEGF.Twist may be helpful for the daignosis and therapy of lung cancer.
出处
《四川医学》
CAS
2011年第8期1175-1178,共4页
Sichuan Medical Journal
