摘要
目的:探讨炎症因子水平对急性冠脉综合征(ACS)合并代谢综合征(MS)诊断的意义。方法:收集2008年12月到2011年1月在我院经冠状动脉(冠脉)造影证实的ACS患者152例,按有无MS分为MS组(78例)和非MS组(74例),测定髓过氧化物酶(MPO)、细胞间粘附分子(ICAM-1)、肿瘤坏死因子(TNF-α)水平,比较两组间各参数水平的差异,根据冠脉造影结果评价其与冠脉病变严重程度的关系。结果:与非MS组比较,MS组血清MPO[(0.68±0.33)μmol/L比(1.99±1.21)μmol/L]、TNF-α[(61.74±7.71)pg/ml比(70.17±7.91)pg/ml]、ICAM-1[(275.09±73.87)pg/L比(292.27±73.87)pg/L]水平显著升高(P均<0.01);MS组总狭窄指数明显高于非MS组[(11.03±3.87)比(6.97±3.68)];冠状动脉病变严重程度与MPO、ICAM-1、TNF-α呈正相关(r=0.5,0.51,0.51,P均<0.01)。结论:髓过氧化物酶、细胞间粘附分子、肿瘤坏死因子水平升高是急性冠脉综合征合并代谢综合征的危险因素,炎症在疾病发生发展过程中起重要作用。
Objective：To explore significance of levels of inflammatory factors in diagnosis of acute coronary syndrome（ACS） complicated metabolic syndrome（MS）.Methods：The data of 152 ACS patients proved by coronary angiography from December 2008 to January 2011 were collected in our hospital,and they were divided into MS group（n=78） and non-MS group（n=74） according to complication of MS.Levels of myeloperoxidase（MPO）,intercellular adhesion molecule-1（ICAM-1） and tumor necrosis factor-α（TNF-α） were measured,and coronary lesion severity was evaluated according to results of coronary angiography.Results：Compared with non-MS group,serum levels of MPO [（0.68±0.33） μmol/L vs.（1.99±1.21） μmol/L],TNF-α [（61.74±7.71） pg/ml vs.（70.17±7.91） pg/ml] and ICAM-1 [（275.09±73.87） pg/L vs.（292.27±73.87） pg/L] significantly increased in MS group（P〈0.01 all）;total stenosis index of MS group was significantly higher than that of non-MS group [（11.03±3.87） vs.（6.97±3.68）];coronary lesion severity was positively correlated with levels of MPO,ICAM-1 and TNF-α（r=0.5,0.51,0.51,P〈0.01 all）.Conclusion：Increased levels of MPO,ICAM–1 and TNF-α is risk factors for acute coronary syndrome complicated metabolic syndrome,and inflammation plays an important role in occurrence and development of disease.
出处
《心血管康复医学杂志》
CAS
2011年第4期310-312,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
2010年度湖南省医药卫生科研计划项目(C2010-015)
