摘要
目的探讨急性冠脉综合征患者的炎症因子水平及室性心律失常发生情况，分析炎症因子水平与室性心律失常的关系。方法将2013年9月～2014年9月于陕西省宝鸡市中医医院心血管内科就诊的186例急性冠脉综合征患者纳入研究，按急性冠脉综合征的诊断标准将患者分为不稳定性心绞痛（UA）组、非ST段抬高性心肌梗死（NSTEM1）组、ST段抬高性心肌梗死（STEMI）组，分别为56、60、70例；按心律失常情况分为无室性心律失常组和继发室性心律失常组，分别为82、104例。采用酶联免疫吸附测定（ELISA）方法检测患者血清可溶性CD40配体（CD40L）、肿瘤坏死因子（TNF—α）和白细胞介素1β（IL-1β）水平。结果在血清TNF-α、IL-1β水平方面，与uA组比较，STEMI组和NSTEMI组明显升高（P〈0．05），STEMI组高于NSTEMI组（P〈0．05）；在血清CD40L水平方面，与UA组比较，STEMI组和NSTEMI组明显升高（P〈0．05），NSTEMI组高于STEMI组（P〈0．05）。与无室性心律失常组比较，继发室性心律失常组患者血清CD40L、TNF-α、IL-1β水平明显升高（P〈0．05）。不同Lown分级室性心律失常患者血清CD40L、TNF—α和IL—1β水平差异有统计学意义（P〈0．05），Pearson相关性分析结果表明，患者Lown分级与血清CD40L、TNF—α和IL-1β水平呈显著正相关关系（P〈0．05）。结论急性冠脉综合征患者室性心律失常可以通过检查患者血清CD40L、TNF—α和IL-1β的水平来进行诊断。
Objective To investigate the levels of inflammatory factors and occurrence of ventricular arrhythmias in patients with acute coronary syndrome, analyze the relationship between the inflammatory factors level and the ventrieular arrhythmias. Methods 186 eases of patients with acute coronary syndrome in Department of Cardiovascular Medicine, Baoji Hospital of Traditional Chinese Medicine from September 2013 to September 2014 were included in this study. According to the diagnostic criteria of acute coronary syndrome, all patients were divided into 3 group： 56 cases of patients in the unstable angina pectoris （UA） group, 60 cases of patients in the non ST segment elevation myocardial infarction （NSTEMI） group, 70 cases of patients in the ST segment elevation myocardial infarction （STEMI） group. Ac- cording to the ventricular arrhythmias condition, patients were divided into the non ventricular arrhythmia group, with 82 cases, and the secondary ventricular arrhythmia group, with 104 cases. Serum soluble CD40 ligand （CD40L）, tumor necrosis factor （TNF-α） and interleukin 1 beta （IL-1 beta） were detected by enzyme-linked immunosorbent assay （ELISA）. Results Compared with the UA group, the serum levels of TNF-α and IL-1β in the STEMI group and the NSTEMI group significantly increased （P 〈 0.05）, which in the STEMI group were higher than those of the NSTEMI group （P 〈 0.05）. Compared with the UA group, the serum level of CD40L in the STEMI group and the NSTEMI group significantly increased （P 〈 0.05）, which in the STEMI group was lower than that of the NSTEMI group （P 〈 0.05）. Compared with the non ventricular arrhythmia group, the serum levels of TNF-α, IL-1β and CD40L in the secondary ventricular arrhythmia group were significantly higher, with statistically significant difference （P 〈 0.05）. There were significant differences in the serum levels of TNF-α, IL-1β and CD40L among ventricular arrhythmias patients with different Lown＇s classification （P
出处
《中国医药导报》
CAS
2016年第23期83-86,共4页
China Medical Herald
