摘要
目的:探讨叶酸、维生素B_(12)对高同型半胱氨酸患者的血清同型半胱氨酸(Hcy)、一氧化氮(NO)水平及心率变异性(HRV)的影响。方法:63例血清Hcy水平增高患者随机分为2组:(1)对照组(30例):不服用叶酸等影响Hcy的药物;(2)干预组(33例):每天口服叶酸、维生素B_(12);治疗前及治疗后4周,测定患者空腹血清Hcy、NO水平,同时行动态心电图检查。所有数据以SPSS 10．0软件包进行统计学处理。结果:干预组Hcy水平与服药前相比降低(P＜0．01);干预组NO水平与服药前相比升高(P＜0．01);对照组Hcy及NO水平亦有变化但无统计学差异(P＞0．05)。干预组患者经治疗后正常窦性RR间期总体标准差(SDNN),每5min窦性RR间期均值标准差(SDANN),正常连续窦性RR间期差值均方根(rMSSD)均较治疗前升高,统计学有显著性差异(P＜0．01)。结论:口服叶酸、维生素B_(12)显著降低了高Hcy血症患者的空腹Hcy水平,升高NO水平,使内皮功能得到改善;同时提高HRV,改善患者的自主神经功能,对于预防心脑血管病的发生有一定价值。
Objective： To explore the effects of folic acid and vitamin B12 on fassting serum homocysteine（Hey）, nitric oxide （NO） and heart rate variability （HRT） in patients with hyperhomocysteine （ HHcy ） levels. Methods： 63 patients with HI-Icy were randomly divided into two groups： Treatment group（33 cases） were given folic acid orally（5mg/d） and vitamin B12（250μg/d） in addition to routine treatment, and the other group（30 cases） were treated with routine treatment as control. The blood samples of the two groups were assayed pre- and post treatment（one month later）, and the concentrations of Hcy and NO were measured and compared. In the meanwhile, HRV were observed in both groups,Results： The Hcy concentration of post treatment was lower than that of pre - treatment in theated group （ P 〈 0.01 ）. The NO levels were lower than those of pre - treatment in theated group（ P 〈 0.01 ） . The difference was not significant in control group （P 〉 0,05）. After 4 weeks treatment, compared with pre - treatment, the HRV obtained improvement, the standard deviation of normal to normal intervals（SDNN） ,SDANN and rMSSD were increased, Conclusion： Folic acid and vitamin BI2 can decrease the serum Hcy content and increase the NO level in patients with HHcy.This therapy can improve the HRV of the patients, It had considerable value to prevent the incidence of cardiovascular and cerebrovascular disease.
出处
《中国医药导刊》
2007年第3期227-228,共2页
Chinese Journal of Medicinal Guide
基金
河北省科学技术研究与发展指导计划课题062761213
