摘要
为探讨人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌遗传易感性之间的关系,文章采用病例-对照研究,对784例肺癌患者和782例性别、年龄、籍贯频数与之相匹配的健康对照中该区域6个标签SNP位点进行基因分型,并统计分析其基因型频率分布与肺癌易感性的关系,以及吸烟在其中的影响。结果发现rs16891561位点TT基因型在60岁以上人群(校正OR=0.42,95%CI=0.20-0.88;P=0.022)、女性人群(校正OR=0.34,95%CI=0.13-0.87;P=0.025)、非吸烟人群中(校正OR=0.32,95%CI=0.13-0.79;P=0.013)对肺癌发生具有保护效应;rs4236926位点TT基因型在60岁以上人群(校正OR=0.48,95%CI=0.23-0.99;P=0.048)、非吸烟人群(校正OR=0.32,95%CI=0.13-0.80;P=0.014)中对肺癌发生具有保护效应,这两种保护效应主要是与腺癌相关。对这两个位点进行累积效应分析发现,含有3-4个变异等位基因型的非吸烟者罹患肺癌的风险显著降低(校正OR=0.29,95%CI=0.11-0.71;P=0.007),并且,含有3-4个变异等位基因型的个体累计吸烟量("包-年"平均数=13.2)与其他个体相比显著降低。由此可见人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌易感性和吸烟行为相关。
To investigate the association between chromosome 8p11(CHRNB3-CHRNA6) polymorphisms and lung cancer susceptibility in Chinese Han population,we genotyped 6 tag SNPs variants of this region among 784 patients with lung cancer and 782 age-and sex-matched cancer-free control participants to screen for any risk-associated SNPs.The results revealed that rs16891561 TT genotype had a protective effect against lung cancer in people over 60 years old(adjusted OR=0.42,95% CI=0.20-0.88;P=0.022),female groups(adjusted OR=0.34,95% CI=0.13-0.87;P=0.025),and non-smoking people(adjusted OR=0.32,95% CI=0.13-079;P=0.013).Additionally,rs4236926 TT genotype had a protective effect against lung cancer in people over 60 years old(adjusted OR=0.48,95% CI=0.23-0.99;P=0.048) and non-smoking people(adjusted OR=0.32,95% CI=0.13-0.80;P=0.014).According to pathological type of lung cancer,these two SNPs were associated with adenocarcinomas susceptibility.As to cumulative effect of rs4236926 and rs16891561,in non-smokers strata,lung cancer risk was significantly reduced in those who had 3-4 mutant alleles(adjusted OR=0.29,95% CI=0.11-0.71;P=0.007).Furthermore,people containing 3-4 mutant alleles had lower level of smoking doses(mean pack-year=13.2) compared with others.In conclusion,8p11(CHRNB3-CHRNA6) polymorphisms are related to smoking behavior and lung cancer susceptibility in Chinese Han population.
出处
《遗传》
CAS
CSCD
北大核心
2011年第8期886-894,共9页
Hereditas(Beijing)
基金
上海市科委重点项目(编号:09JC1402200)
上海市国际合作项目(编号:10410709100)
上海市重点学科建设项目(编号:B111)资助