摘要
目的探讨人染色体X连锁凋亡抑制蛋白（XIAP）基因3＇非翻译区（3＇UTR）rs9856位点多态性与中国汉族人群急性胰腺炎遗传易感性之间的关系。方法采用病例一对照研究，对320例急性胰腺炎患者和320例性别、年龄、籍贯频数与之相匹配的健康对照组的rs9856位点进行基因分型，并统计分析其基因频率分布与急性胰腺炎易感性的关系。结果发现等位基因比如下：病例组C／T=1．08，对照组C／T=1．51；2组C／T卡方检验P=0．003，差异具有统计学意义。这表明该位点C／T分布在胰腺炎和正常人群中有显著区别；进一步对该位点按照病情严重程度分层分析结果显示，TT型基因与CC型相比对轻症急性胰腺炎的发生具有保护作用[OR=0．59，95％CI=（0．40～0．86），P=0．006]。结论人染色体XIAP-3＇UTR区域rs9856位点多态性与中国汉族人群急性胰腺炎易感性相关。
Objective To investigate the association between the rs9856 variant polymorphism of human chromosome X -linked inhibitor of apoptosis protein （XIAP） -3＇UTR and the susceptibility to acute pancreatitis in Han Chinese. Methods 320 acute pancreatitis patients and 320 healthy subjects were enrolled to identify XIAP -3＇UTR rs9856 genotypes and investigate the relationship between the genetic polymorphism and acute pancreatitis susceptibility. Results The allele ratio of C/T was 1.08 in the patient group, and 1.51 in the control group. According to X2 analysis, P = 0. 003, indicating a significant difference between the two groups. Based on disease severity analysis, TT genotype had a stronger protective effect on slight pancreatitis patients than CC genotype [ （OR = 0.59, 95% CI = （0.40 -0.86） , P = 0. 006]. Conclusion Rs9856 variant polymorphism of XIAP- 3＇UTR is correlated with the susceptibility to acute pan- creatitis in Han Chinese.
出处
《徐州医学院学报》
CAS
2014年第4期234-238,共5页
Acta Academiae Medicinae Xuzhou
