摘要
目的探讨异基因联合脐带间充质干细胞(Mesenchymal Stem Cell,MSC)移植术的护理。方法采取规范的治疗方案护理,严格控制脐带MSC、外周造血干细胞(PBSC)、骨髓干细胞输入时间及方法,注意观察病情,加强aGVHD皮肤、肠道及肝脏护理。结果联合移植后1个月复查患者嵌合体均为100%完全供者嵌合;白细胞植入中位时间13.5d,血小板植入中位时间14d;半年内无死亡病例。结论对移植后发生的植入综合征、感染及出血性膀胱炎并发症采取有效的预防和护理是保证移植术成功的关键。
Objective To study the nursing of patients after human umbilical cord-derived mesenchymal（HUC-MSC） and allogenenic hematopoietic stem cell transplantation（allo-HSCT）.Methods Patients were nursed according to their standard treatment program and nursing measures.The infusion time and methods of HUC-MSC,peripheral blood stem cells（PBSC） and bone marrow stem cells were strictly controlled.Condition of the patients was observed.Nursing of the patients with acute graft-versus-host disease（GVHD）,intestine and liver diseases was intensified.Results The chimerism was completely achieved in all patients one month after HSCT.The median time of white cell and platelet transplantation was 13.5 days and 14 days,respectively.No death occurred in six months after operation.Conclusion Effective nursing of patients and prevention of implantation syndrome,infection and hemorrhagic cystitis after HUC-MSC and allo-HSCT are the key to successful transplantation.
出处
《军医进修学院学报》
CAS
2011年第8期844-846,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
脐带间充质干细胞
异基因移植
护理
Umbilical Cord Mesenchymal Stem Cell
Allogenenic Transplantation
Nursing Care
