摘要
目的了解同一地区不同医疗机构医院感染嗜麦芽寡养单胞菌的临床分布及耐药性,为临床治疗及预防提供依据。方法回顾性分析不同医院2007年1月-2009年12月医院感染嗜麦芽寡养单胞菌的临床分布及其药敏结果。结果两所医院嗜麦芽寡养单胞菌均主要分离自重症监护病房,分别占49.4%、62.5%,临床标本分布均以痰液为主,占91.0%、90.3%;药敏试验结果显示,均对亚胺培南完全耐药,对头孢吡肟、氨苄西林/舒巴坦、妥布霉素、阿米卡星和庆大霉素耐药率>80.0%;两所医院嗜麦芽寡养单胞菌均对磺胺甲噁唑/甲氧苄啶耐药率最低,分别为6.7%和5.8%。结论嗜麦芽寡养单胞菌多发生在基础疾病重的患者,对多种抗菌药物耐药,同一地区不同医院耐药性总体上相同,但是也存在一定差异,临床治疗应根据病原学检查及药物敏感试验合理选用抗菌药物。
OBJECTIVE To investigate the clinical distribution and drug resistance of Stenotrophomonas maltophilia in different hospitals of the same region and provide evidence for proper choose of antibiotics.METHODS The result of drug susceptibility and clinical distribution of S.maltophilia from Jan 2007 to Dec 2009 were analyzed and studied retrospectively.RESULTS Concerning the ward distribution of S.maltophilia,ICU had the highest rates of 49.4% and 62.5% in the two hospital.The isolation rates were the highest in the respiratory specimens.There was a highest isolation rate of 91.0% or 90.3%,the result of drug sensitive test showed that the resistance rates to imipene had the highest（100.0%）.The resistance rates to some antibiotics including cefepime,ampicillin/sulbatam,tobromycin,amikacin,gentamicin,etc were higher than 80.0%.Sulfamethoxazole/trimethoprim had the lowest drug resistance of 6.7% and the lowest drug resistance of 5.8%.CONCLUSION S.maltophilia occurs mainly in patients with severe underlying diseases,which show multiple drug resistance.It is similar with the drug resistance in general,however there are some differences in two hospital.Therefore,it is necessary to choose the antibiotics sensitive to S.maltophilia according to the clinical distribution and the result of drug sensitive test.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第16期3486-3488,共3页
Chinese Journal of Nosocomiology
关键词
嗜麦芽寡养单胞菌
医院感染
临床分布
耐药性
Stenotrophomonas maltophilia
Hospital infection
Clinical distribution
Drug resistance
