摘要
埃博霉素是以微管为靶点的大环内酯类药物。已经或正在开发的几种埃博霉素类药物有:埃博霉素B内酰胺衍生物、埃博霉素D、埃博霉素B、埃博霉素F、埃博霉素A,其中埃博霉素D内酰胺衍生物极有可能成为高效候选抗肿瘤新药。本文从结构特点和作用机制出发,重点综述埃博霉素B、D及其衍生物的研发进展。
Epothilones are natural macrolides targeting microtubule.The epothilones which have been or are being developed are aza-epothilone B,epothilone D,epothilone B,epothilone F,epothilone A.Aza-epothilone D has high potential to become an effective candidate of antitumor agent.From the structure and mechanism,this review summarizes the research progress of epothilone B,D and their derivatives.
出处
《世界临床药物》
CAS
2011年第7期416-419,共4页
World Clinical Drug
