摘要
目的探讨阿立哌唑和利培酮对男性精神分裂症患者疗效及性功能的影响。方法将60例精神分裂症患者随机分为阿立哌唑组30例和利培酮组30例，对两组进行为期8周的前瞻性对照研究。检测两组患者血清泌乳素（PRL）水平。使用简明男性性功能量表、阳性与阴性综合征量表（PANSS）评估性功能及精神症状，用副反应量表（TESS）评估药物治疗的不良反应。结果治疗第8周末，利培酮组的性功能量表总分及因子分均较治疗前降低（P〈0．05或P〈0．01），阿立哌唑组得分无明显变化。利培酮组治疗第8周末的血清PRL水平高于基线水平（P〈0．01），阿立哌唑组无明显变化。结论阿立哌唑对男性性功能的影响对男性精神分裂症患者是一种较为安全、有效的抗精神病药物。
Objective To study the clinical efficacy of aripiprazole and risperidone in treatment of male patients with schizophrenia and their influence on sexual function. Methods Sixty male patients with schizophrenia were randomly divided into aripiprazole group（n=30） and risperidone group（n=30）, The serum levels of prolactin of patients in each group were measured, meanwhile all patients were assessed with brief male sexual function scale, the positive and negative syndrome scale （PANSS） and treatment emergent symptom scale （TESS） before treatment and 8 weeks later. Results After 8-weeks treatment, the factor scores and total score of brief male sexual function scale were all decreased in risperidone group（P〈0.05 or P〈0.01）. No change in scores of brief male sexual function scale was found in aripiprazole group. The level of serum prolactin was significantly higher in risperidone group after 8-week treatment than that at the baseline level. There was no significant change in aripiprazole group. Conclusion Aripiprazole is an effective and safe drug for treatment of the male patients with schizophrenia.
出处
《中国男科学杂志》
CAS
CSCD
2011年第4期20-22,26,共4页
Chinese Journal of Andrology
关键词
阿立哌唑
利培酮
精神分裂症
性功能
Aripiprazole
Risperidone
schizophrenia
sexual function
