摘要
目的探讨首发和复发抑郁症患者血清S100B蛋白及其分泌型糖基化终产物受体(esRAGE)浓度的改变。方法采用酶联免疫方法检测34例抑郁症患者(首发15例,复发19例)和34名正常对照的血清S100B、esRAGE蛋白浓度,比较患者组和对照组间的差异;采用17项汉密尔顿抑郁量表(Hamilton Depression Rating Scale-17,HAMD-17)评定患者的症状,分析上述两个生化指标与症状之间的关系。结果总体患者组血清S100B浓度高于对照组[(0.57±0.04)ng/mL vs(0.38±0.12)ng/mL,P<0.01],esRAGE浓度低于对照组[(0.52±0.11)ng/mL vs(0.66±0.10)ng/mL,P<0.01];首发和复发患者组之间血清S100B浓度与esRAGE的差异均有统计学意义[(0.46±0.01)ng/mL vs(0.57±0.02)ng/mL,P<0.01;(0.44±0.02)ng/mL vs(0.53±0.10)ng/mL,P<0.01];与对照组相比,首发及复发患者组的血清S100B浓度均升高而esRAGE浓度均下降,差异均有统计学意义(P<0.01)。未见患者组的血清S100B、esRAGE浓度相关或二者与HAMD评分相关(P>0.05)。结论血浆S100B、es-RAGE可能在抑郁症的发病中起了一定的作用,复发患者神经胶质细胞分泌S100B能力可能更强。
Objective To investigate the association of serum S100B and esRAGE protein levels with traits of major depression. Methods The serum S100B and esRAGE levels in 34 major depressive patients including 15 cases of first episode, 19 cases of recurrence in depression group and 34 healthy volunteers in control group were examined using enzyme linked immunosorbent assay （ ELSIA ）. Depression symptoms were assessed using the Hamilton Depression Rating Scale （HAMD） and the associations between serum S100B and esRAGE levels with traits of the disorder were analyzed in depression group. Results The serum S100B levels were significantly higher in depression group than in control group（0.57 ±0. 04 ng/ml VS 0.38 ±0. 12ng/ml, P 〈 0.01 ）, on the contrast, serum esRAGE levels was significantly lower in depression group than in control group[ （0.52 ± 0.11 ）ng/ml vs （0.66 ± 0.10）ng/ml,P 〈 0.01 ） ]. The serum S100B and esRAGE levels were significant different between first episode and recurring subgroups in depression group[ （0.46± 0.01 ）ng/ml vs （0.57 ±0.02） ng/ml, P 〈 0.01 ; （0.44±0.02 ） ng/ml vs （0.53±0.10） ng/ml, P 〈 0.01 ） J. Compared with controls, both first episode and recurring patients had significantly higher levels of S100B and lower levels of esRAGE （ P 〈 0.01 ）. Serum SI00B levels were not correlated with esRAGE levels （P 〉 0.05）. Serum S100B and esRAGE levels were not correlated with HAMD scores in depression group （P 〉 0.05）. Conclusions Serum S100B and esRAGE levels may be a biomarker for major depression. Serum S100B and esRAGE levels are lower in first episode subgroups than in recurring subgroups, which suggest that Serum S100B and esRAGE levels may increase with the number of episode.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2011年第7期418-420,共3页
Chinese Journal of Nervous and Mental Diseases
基金
广东省医学科研基金项目(编号:A2009602)
深圳市科技计划项目(编号:200903127)
