摘要
目的探讨前列地尔对急性脑干梗死患者预后及血清白细胞介素-6(IL-6)、S100B及肿瘤坏死因子?α(TNF?α)水平的影响。方法选取82例急性脑干梗死患者,随机分为观察组和对照组,各41例。在常规治疗基础上,观察组静脉滴注前列地尔,对照组静脉滴注奥扎格雷钠,疗程2周。比较2组临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)和Barthel指数(BI)评分,治疗前及治疗第3、14天血清IL-6、S100B及TNF?α水平的变化,及不良反应情况。结果观察组临床总有效率显著高于对照组(P<0.05)。治疗后,2组NIHSS评分较治疗前显著下降,而BI评分显著增加(P<0.05或P<0.01),其中观察组改善显著优于对照组(P<0.01)。治疗后,2组血清IL-6、S100B及TNF?α水平均较治疗前有不同程度的下降,其中治疗第14天下降更为明显;观察组治疗第14天血清IL-6、S100B及TNF?α水平显著低于对照组(P<0.01)。治疗期间,2组均未见严重不良反应发生。结论前列地尔可有效降低急性脑干梗死患者血清IL-6、S100B和TNF?α水平,减轻脑组织损伤,改善预后。
Objective To investigate the influence of prostaglandin E1（ PGE1） on prognosis and serum levels of interleukin-6（ IL-6）,S100 B and tumor necrosis factor-α（ TNF-α） in patient with acute brain stem infarction. Methods A total of 82 patients with acute brain stem infarction were randomly divided into observation group and control group,41 cases in each group. On the basis of conventional treatment,the observation group was treated with intravenous PGE1 and the control group was treated with sodium ozagrel. The course of treatment was 2 weeks. The clinical effects,outcomes of National Institutes of Health Stroke Scale（ NIHSS） and Barthel Index（ BI） were compared. The levels of IL-6,S100 B and TNF-α were also compared at the time points of before treatment,3 and 14 days after treatment. Results In the observation group,the effective rate was significantly higher than the control group（ P〈0. 05）. There were significant decrease of NIHSS and increase of BI in both groups after treatment（ P〈0. 05 or P〈0. 01）,and the observation group achieved a better outcome（ P〈0. 01）. Levels of IL-6,S100 B and TNF-α decreased in both groups after treatment. At the 14 th day,the levels of IL-6,S100 B and TNF-α were significant lower in the observation group than those in the control group（ P〈0. 01）. No severity adverse events were observed in both groups. Conclusion PGE1 can reduce levels of IL-6,S100 B and TNF-α in patients with acute brain stem infarction,alleviate brain damage and improve prognosis.
出处
《实用临床医药杂志》
CAS
2015年第11期15-18,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11520984)
