摘要
目的血清S100B蛋白浓度可提示患者脑卒中后脑损伤情况。文中分析卒中后伴抑郁症状患者血清S100B蛋白的特征及抗抑郁治疗前后变化情况。方法收集2014年1月至2015年6月期间湖州市第三人民医院符合卒中后抑郁诊断标准的住院患者95例。在排除不愿及不能完成测试患者后,最终纳入52例进入研究,并接受艾司西酞普兰抗抑郁治疗8周。采用汉密尔顿抑郁量表(HAMD-17)评定患者抑郁症状及疗效。治疗前及治疗终点分别测定研究对象血清S100B蛋白浓度;另招募年龄、性别匹配脑卒中后康复患者36例以及36例健康对照人群测定血清S100B浓度进行比较。疗效以治疗8周末HAMD评分减分率进行评定,HAMD减分率≥50%为有效。结果卒中后抑郁、康复患者以及正常对照者血清S100B蛋白浓度分别为(0.44±0.14)、(0.36±0.09)和(0.21±0.10)μg/L,组间比较差异有统计学意义(F=41.88,P<0.05);治疗前男、女卒中后抑郁患者血清S100B蛋白浓度分别为(0.46±0.16)和(0.43±0.14)μg/L,差异无统计学意义(t=0.706 2,P=0.483 3);缺血性脑卒中与出血性脑卒中患者血清S100B蛋白浓度分别为(0.42±0.12)和(0.47±0.15)μg/L,差异无统计学意义(t=1.309 7,P=0.196 3);治疗后有效与无效患者血清S100B蛋白浓度降低值分别为(0.13±0.03)和(0.04±0.01)μg/L,差异有统计学意义(t=11.659 5,P<0.05)。结论卒中后抑郁患者血清S100B蛋白浓度显著升高,与性别及卒中类型无关。治疗后血清S100B蛋白下降明显可提示抗抑郁治疗疗效良好。
Objective The serum S100 B level reflects brain injury after stroke.This study was to explore the features of serum S100 B in post-stroke depression patients and its change after anti-depression treatment.Methods Totally 52 of the 95 poststroke depression inpatients were included in this study.All the patients were treated with escitalopram for 8 weeks followed evaluation of their depression status and the therapeutic effects with Hamilton Depression Scale-17.The serum S100 B concentration was detected before and after the treatment.Thirty-six post-stroke patients without depression and another 36 normal controls were recruited for comparison of the serum S100 B concentration.Response is defined as the reduction rate of HAMD-17 ≥50% after the treatment.Results The serum S100 B levels of the post-stroke depression patients,nondepression post-stroke patients,and normal controls were（[0.44 ±0.14] vs [0.36 ± 0.09] vs [0.21 ± 0.10] μg/L,F=41.88,P =0.000）,those of the male and female post-stroke depression patients at the baseline were（[0.46 ± 0.16]vs [0.43 ± 0.14]μg/L,t=0.706 2,P=0.483 3）,and those of the ischemic stroke and hemorrhagic stroke patients at the baseline were（[0.42 ± 0.12] vs [0.47 ± 0.15] μg/L,t=1.309 7,P=0.196 3）.The reductions of the S100 B level in the response and non-response groups were（[0.13 ± 0.03]vs [0.04 ± 0.01]μg/L,t=11.659 5,P=0.000 0）.Conclusion The serum S100 B level in post-stroke depression patients is higher than in non-depression post-stroke patients and normal controls,which is not associated with gender or stroke types.The decrease of serum S100 B predicts the efficacy of anti-depression treatment.
出处
《医学研究生学报》
CAS
北大核心
2016年第7期737-740,共4页
Journal of Medical Postgraduates
基金
湖州市科技局项目(2014GYB06)
