摘要
观察家兔对青藤祛湿外敷散的长期毒性反应.取家兔50只进行长期毒性试验,随机平均分为1个对照组和4个实验组,每组10只,均剔去脊柱两侧共150 cm2毛.各组连续经皮用药8周后和恢复期2周后,进行血液学、血液生化、脏器重量系数、组织病理学检查及常规观察.各组家兔的各项指标与对照组比较,均无显著性差异(P>0.05).青藤祛湿外敷散是一种安全,无毒的药物.
To observe the long term toxicity of sinomenine dehygrosis pulvis. 50 rabbits were divided into 5 groups randomly, four experiment team and one control team , each one with 150 cm^2 molted on both sides of backbone to take the long term toxicity of sinomenine dehygrosis pulvis. The term of treatment in all 5 groups lasted eight weeks and recovered two weeks. Indices of hematology and blood biochemistry, weight coefficients of organs, histopathology of various organs were subjected to systematic examinations. It turned out that all the indices of each groups had no obvious difference from that of control group. Sinomenine dehygrosis pulvis can be regarded as a safety and nonpoisonous drug.
出处
《哈尔滨商业大学学报（自然科学版）》
CAS
2011年第3期263-266,共4页
Journal of Harbin University of Commerce：Natural Sciences Edition
基金
黑龙江中医药大学新药研究基金(X200903)
关键词
青藤祛湿外敷散
经皮给药
长期毒性试验
sinomenine dehygrosis pulvis
percutaneous administration
long term toxicity test
