摘要
[目的]观察2型糖尿病（T2DM）合并非酒精性脂肪肝（NAFLD）患者血清高敏C反应蛋白（hs-cRP）水平、及其与大血管病变的关系。【方法】将187例T2DM患者分为T2DM合并NAFLD组及T2DM无NAFD组。测定体重指数（BMI）、腰围（WL）、空腹血糖（FPG）、空腹C肽（FCP）、低密度脂蛋白（LDL-C）、甘油三酯（TG）、糖化血红蛋白（HbAlC）、丙氨酸氨基转移酶（ALT）、血清hs-CRP水平、颈动脉内膜中层厚度（IMT）、颈动脉斑块发生率、肱踝指数（ABI），及大血管病变发生率评估。【结果】与T2DM无NAFLD组比较，T2DM合并NAFLD组BMI、wC及血清TG、FPG、FCP、ALT、hs-CRP水平明显增高，IMT、颈动脉斑块发生率、大血管病变发生率增加，而ABI明显降低（P均〈0．05）。【结论】T2DM合并NAFLD患者IMT增加，ABI明显降低，颈动脉斑块发生率及大血管病变发生率增加；hs-CRP参与了颈动脉斑块及大血管病变的形成。
[Objective] To observe the relationship between serum level of high sensitivity C-reactive protein（hs-CRP） and macroangiopathy in type 2 diabetes mellitus（T2DM） patients complicated with nonalcoholic fatty liver disease（NAFLD）. [Methods] Totally 187 patients with T2DM were divided into NAFLD group and non-NAFLD group. The body mass index（BMI）, waist circumference（WL）, fasting C-peptide（FCP）, low density lipoprotein（LDL-C）, triglyeeride（TC）, glyeosylated hemoglobin（HbA1C）, alanine aminotransferase （ALT）, serum hs-CRP level, carotid intima-media thickness（IMT）, the incidence of atherosclerotic plaque, ankle brachial index（ABI） and the incidence of macroangiopathy were measured and evaluated. [Results] Compared with T2DM without NAFLD group, the BMI, WC and serum levels of TC, FPG, FCP, ALT and hs-CRP in T2DM with NAFLD group obviously increased, and the IMT and the incidence of atherosderotic plaque and macroangiopathy increased, while ABI decreased significantly（all P %0.05）. [Conclusion] The IMT of T2DM patients complicated with NADLD increases, and the ABI decreases obviously, and the incidence of atherosclerotiee plaque and macroangiopathy also increases. The hs-CRP may be involved the development of atherosclerotic plaque and macroangiopathy.
出处
《医学临床研究》
CAS
2011年第6期1075-1077,共3页
Journal of Clinical Research
