摘要
目的 探讨血清超敏C反应蛋白(hs-CRP)与老年人非酒精性脂肪肝(NAFLD)间的关系,为防治NAFLD提供依据。方法 调查2013年3—11月符合研究条件的2 124名年龄60岁及以上宁波市镇海区某石化企业退休员工,测量腰围、血压、体重指数、空腹血糖、尿酸、血脂谱、肝功能、hs-CRP和腹部B超结果。按hs-CRP水平的四分位数分为Q1组为≤0.4 mg/L(n=667),Q2组为>0.4 mg/L~≤0.7 mg/L(n=437),Q3组为>0.7 mg/L~≤1.4 mg/L(n=515),Q4组为>1.4 mg/L(n=505),NAFLD患病危险因素采用logistic回归分析。结果 老年人NAFLD的患病率为25.8%(548/2 124);随着年龄的增长,患病率逐渐降低差异有统计学意义(P<0.05),Q1、Q2、Q3、Q4组的NAFLD患病率为13.2%(88/667)、24.5%(107/437)、32.6%(168/515)、36.6%(185/505),患病率逐渐增高,差异有统计学意义(χ^(2)=99.246,P<0.001);多因素logistic回归分析显示升高的血清hs-CRP是老年人患NAFLD的危险因素,未校正相关因素前Q2、Q3、Q4分组的NAFLD患病风险分别是Q1的2.133、3.185、3.804倍,校正相关因素后分别是Q1组的1.554、1.828、1.895倍。结论 升高的血清hs-CRP是老年人NAFLD患病的独立危险因素。
Objective To investigate the relationship between serum hypersensitive C-reactive protein(hs-CRP)and nonalcoholic fatty liver disease(NAFLD)in the elderly,and provide the basis for prevention and treatment of NAFLD.Methods A total of 2124 senior citizens aged 60 and above in a petrochemical enterprise in Zhenhai District,Ningbo City were investigated from March to November 2013,and their waist circumference,body mass index,blood pressure,fasting blood glucose,uric acid,blood lipid profile,liver function,hs-CRP and upper abdominal B-ultrasound were measured.Groups were categorized by quartiles of hs-CRP levels as fllows:group Q1(≤0.4 mg/L,n=667),Q2(>0.4 mg/L-≤0.7 mg/L,n=437),Q3(>0.7 mg/L-≤1.4 mg/L,n=515),and Q4(>1.4 mg/L,n=505).The risk factors of NAFLD were analyzed by logistic regression.Results The prevalence of NAFLD in the elderly was 25.8%(548/2124),and with the growth of age,the prevalence rate gradually decreases(P<0.05).The prevalence of NAFLD in Q1,Q2,Q3 and Q4 groups were 13.2%(88/667),24.5%(107/437),32.6%(168/515)and 36.6%(185/505),respectively,and the prevalence gradually increased(x?=99.246,P<0.001).Multivariate unconditional logistic regression analysis showed that elevated serum hs-CRP was an independent risk factor for NAFLD in the elderly.The prevalence of NAFLD in Q2,Q3 and Q4 groups before the adjustment of the relevant factors were 2.133,3.185,3.804 times of Q1,and 1.554,1.828,1.895 times of Q1 group after the adjustment of the relevant factors.Conclusion Elevated serum hs-CRP is an independent risk factor for NAFLD in the elderly.
作者
陈长喜
杜娟
宋健
张丞
李梦婷
李红亮
CHEN Changxi;DU Juan;SONG Jian;ZHANG Cheng;LI Mengting;LI Hongliang(Department of Gastroenterology,the Affliated People's Hospital of Ningbo University,Ningbo,Zhejiang 315000,China;不详)
出处
《中华全科医学》
2023年第9期1491-1494,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2022KY1182)
宁波市自然基金项目(2017A610276)
宁波市鄞州区农社科类科技项目(2021AS0053)。
关键词
老年人
非酒精性脂肪肝
超敏C反应蛋白
流行病学
Elderly
Non-alcoholic fatty liver disease
Hypersensitive C-reactive protein
Epidemiologic
