期刊文献+

肿瘤整合素αvβ3受体显像的研究进展 被引量:1

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摘要 1971年,Folkman提出"肿瘤的生长和转移都依赖于新生血管的生成"的观点。该观点认为任何实体瘤的生长与转移均有赖于新生的血管形成(angiogenesis),缺乏新的血管形成,肿瘤的生长很难超过3 mm,只有新的血管形成后,肿瘤才能迅速增长。临床上也发现肿瘤的新生血管密度与癌转移及患者的存活率相关。于是,抗血管形成为治疗肿瘤的一种新概念。
出处 《中国实验诊断学》 北大核心 2011年第6期1127-1130,共4页 Chinese Journal of Laboratory Diagnosis
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参考文献23

  • 1Folkman J. Tumor angiogenesis: therapeutic implications [ J]. N Engl J Med, 1971,285(21) : 1182. 被引量:1
  • 2Vonlaufen A, Wiedle G, Borisch B, et al. Integrinαvβ3 Expression in Colon Carcinoma Correlates with Survival [ J ]. Modem Pathol, 2001, 14 ( 1 ) : 1126. 被引量:1
  • 3Mizeje W, Gerald J. Role of integrins in cancer: survey of expression pat- tems[J]. Pro Soe Exp Biol Med, 1999,222(2):124. 被引量:1
  • 4Plow EF,Haas TA,Zhang L, et al. Ligand binding to integrins[J]. J Biol Chem, 2000,275 (29) :21785. 被引量:1
  • 5Vamer A J, Cheresh DA. Integrins and cancer [ J]. Curt Opin Cell Biol, 1996,8(4) :724. 被引量:1
  • 6Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 trig- gers the angiogenic switch during carcinogenesis[J]. Nat Cell Biol,2000,2 ( 10 ) : 737. 被引量:1
  • 7Napoleone Ferrara. Vascular endothelial growth factor: basic science and clinical progress[J]. Endocrine Reviews,2004,25(4) :581. 被引量:1
  • 8Bao W, Stromblad S. Integrin t alpha I v-med/ated inactivation of p53 con- trois a MEKl-dependent melanoma cell survival pathway in three-dimen- sional collagen. This indicates that integrin alphav-mediated inactivation of p53[J]. J Cell Biol,2004,167(4) :745. 被引量:1
  • 9Janson ET, Westlin JE, Ohrvall U, et al. Nuclear localization of 111 In after intravenous injection of [ 1 11In-DTPA-D-Phel]-octreotide in patients with neuroendocrine tumors[J]. J Nucl Med, 2000,41 (9) : 1514. 被引量:1
  • 10Max R, Gerritsen R R, Nooijen P T, et al. Immunohistochemical analysis of integrin alpha v beta3 expression on tumor-associated vessels of human carcinomas[J]. Int J Cancer, 1997,71 (3) : 320. 被引量:1

二级参考文献30

  • 1Allman R, Cowburn P, Mason M. In vitro and in vivo effects of a cyclic peptide with affinity for the αvβ3 integrin in human melanoma cells[J]. Eur J Cancer, 2000,36(3):410. 被引量:1
  • 2Su ZF, Liu G, Gupta S, et al. In vitro and in vivo evaluation of a technetiun-99m-labeled cyclic RGD peptide as a specific marker of alpha(v)beta(3) integrin for tumor imaging[J]. Bioconjug Chem,2002,13(3):561. 被引量:1
  • 3Haubner R, Bruchertseifer F, Bock1 M. et al. Synthesis and biological evaluation of a 99mTc-labelled cyclic RGD peptide for imaging the αvβ3 expression [J]. Nucl Med,2004, 43(1): 26. 被引量:1
  • 4Mizeje W, Gerald J. Role of integrins in cancer: survey of expression patterns[J] .Pro Soc Exp Biol Med, 1999,222(2):124. 被引量:1
  • 5Yarner AJ, Cheresh DA.Integrins and cancer[J]. Curr Opin Cell Biol,1996,8(4) :724-730. 被引量:1
  • 6Carton CP, Meyer DM, Pegg JA, et al. A peptidomimetic antagonist of the integrinανβ3 inhibits leydig cell tumor growth and the development of hypercalcemia of malignanoy [ J ]. Cancer Res, 1998,58 (9) : 1930-1933. 被引量:1
  • 7Zheng DQ,Woodard AS,Fornaro M,et al.prostatic carcinoma cell migration via alpha(v)beta(3) integrin is modulated by focal adhesion kinase pathway[J]. Cancer Res, 1999,59(2) : 1655-1664. 被引量:1
  • 8Vonlaufen A, Wiedle G, Borisch B, et al. Integrin ανβ3 Expression in Colon Carcinoma Correlates with Survival[J]. Modem Pathol,2001,14(1):1126-1132. 被引量:1
  • 9Byzova TV, Rabbani RR, Dsouza SE, et al. Role of integrin ανβ3 in vascular biology[J] .Thromb Haemostasis,1998,80(2):726-734. 被引量:1
  • 10Haubner R,Bruchertseifer F, Bockl M, et al. Synthesis and biological evaluation of a ^99mTc -labelled cyclic RGD peptide for imaging the ανβ3 expression[J] .J Nucl Med,2004,43(1):26-32. 被引量:1

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