摘要
精氨酸-甘氨酸-天冬氨酸（RGD）肽仔在于多种生物细胞外基质中，能特异性识别细胞表面整合素并与之结合，从而介导多种审要的生命活动。外源性RGD肽与肿瘤细胞表面整合素结合后，可作为体内RGD肽类物质的竞争性抑制剂，抑制肿瘤细胞与细胞外基质的黏附与迁移、抑制肿瘤血管形成、诱导肿瘤细胞凋亡，且具有靶向性标记肿瘤显像以及作为抗肿瘤药物和基因治疗的靶向性传导系统的作用。
RGD peptides exist in extracelular matrix of many kinds of organisms,and they can specificly recognise and combin with integrin receptors. After combining with integrin receptors, extrinsic RGD peptides can prevent tumor cells them adhering and migrating, suppress agiogenesis and induce trunor cells apoptosis. And the derivates of RGD peptides can be used as specific imaging libelling and targetal drug dilivery system for tumor therapy.
出处
《国际放射医学核医学杂志》
2007年第5期274-277,共4页
International Journal of Radiation Medicine and Nuclear Medicine
