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血管内皮生长因子和内皮抑素对血管生成的作用研究进展 被引量:2

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摘要 血管内皮生长因子(VEGF)是一种多功能糖蛋白,是由肿瘤细胞或宿主的非内皮细胞分泌的特异的内皮细胞有丝分裂因子,是最主要的促进血管生成因子。它具有促进血管通透性增加、血管内皮细胞分裂、增殖及诱导血管生成等作用。内皮抑素(ES)是胶原XⅧc末端降解片段,体内、体外实验表明内皮抑素能有效抑制血管内皮细胞增殖、迁移及新生血管形成,是一种特异性的目前为止作用最强的血管形成抑制剂。但其确切的抗血管形成的作用机制尚未阐明。现就血管内皮生长因子、内皮抑素在血管生成中的作用作一综述。
出处 《中国优生与遗传杂志》 2008年第8期123-124,48,共3页 Chinese Journal of Birth Health & Heredity
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