摘要
目的研究大叶鼠尾草中的化学成分。方法利用正相硅胶、Sephadex LH-20、ODS等柱色谱技术对其乙醇提取物进行分离纯化,根据它们的理化性质和波谱数据鉴定化合物结构。结果得到11个化合物,分别鉴定为丹参酮I(tanshinone I,1),丹参酮ⅡA(tanshinoneⅡA,2),丹参内酯(tanshinlactone,3),β-谷甾醇(β-sitosterol,4),隐丹参酮(cryptotanshinone,5),chrysene(6),methyl rosmarinate(7),ethyl rosmarinate(8),norsalvioxide(9),1,2-二氢丹参醌(1,2-dihydrotanshinone-I,10),丹参酮ⅡA酐(anhydride of tanshinone-Ⅱ,11)。结论化合物6～8为该属植物首次分离,其他化合物为首次从该植物中分离得到。
OBJECTIVE To study the chemical constituents of Salvia grandifolia.METHODS The compounds were isolated by silica gel,sephadex LH-20 and RP-C18 column chromatography,and their structures were elucidated by physico-chemical properties and spectral analysis.RESULTS Eleven compounds were isolated and identified as：tanshinone I（1）,tanshinoneⅡA（2）,tanshinlactone（3）,β-sitosterol（4）,cryptotanshinone（5）,chrysene（6）,methyl rosmarinate（7）,ethyl rosmarinate（8）,norsalvioxide（9）,1,2-dihydrotanshinone-I（10）,anhydride of tanshinone-ⅡA（11）.CONCLUSION Compound 6-8 were isolated from the genus ofSalvia for the first time,and the other compounds were for the first time isolated from this plant.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2011年第13期977-979,共3页
Chinese Pharmaceutical Journal
基金
国家科技重大专项资助项目(2009ZX09302-003)
关键词
鼠尾草属
大叶鼠尾草
丹参酮
二萜
化学成分
Salvia
Salvia grandifolia
tanshinone
diterpene
chemical constituents
