摘要
目的探讨辛伐他汀联合尼莫地平对蛛网膜下腔出血(SAH)的治疗作用。方法将96例原发性SAH患者随机分为治疗组和对照组,对照组给予常规治疗,治疗组在常规治疗基础上给予辛伐他汀联合尼莫地平治疗。比较两组患者神经功能缺损情况和脑血管痉挛、脑积水、再出血的发生率及病死率。结果治疗组较对照组患者神经功能缺损评分、脑血管痉挛、脑积水发生率及病死率明显降低(P<0.05),而再出血与对照组比较差异无统计学意义(P>0.05)。结论辛伐他汀联合尼莫地平能明显改善SAH患者的神经功能,同时可以减少SAH后脑血管痉挛和脑积水的发生,降低病死率。
Objective To explore the therapeutic effect of simvastatin combined with nimodipine in the treatment of subarachnoid hemorrhage （SAH）. Methods Ninety-six patients with SAH were randomly divided into the treatment group and the control group. Patients in the control group were treated with routine therapy, and patients in the treatment group were given simvastatin combined with nimodipine on the basis of routine therapy. The scores of neurological impairment,the incidence of cerebral vasospasm, the incidence of hydrocephalus, the incidence of rebleeding and mortality rate between the two groups were compared. Results Neurological impairment scores, the incidence of cerebral vasospasm, the incidence of hydrocephalus and mortality rate in the treatment group were significandy lower than those in control group （ P 〈 0. 05 ）, but the incidence of rebleeding showed no statisical significance between two groups （P 〉 0. 05）. Conclusion Simvastatin combined with nimodipine can evidently improve the neurological function in patients with SAH, and reduce the incidence of cerebrel vasospasm, and hydrocephalus, and mortality rate after SAH.
出处
《中国临床新医学》
2011年第6期530-532,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
