摘要
目的比较分析蛛网膜下腔出血后脑血管痉挛患者采用不同途径和剂量尼莫地平进行治疗的临床效果。方法选择2017年1月至2019年1月在本院接受治疗的150例蛛网膜下腔出血后脑血管痉挛患者,通过随机分组的方式分成A、B、C、D、E组,每组30例。A组采用口服低剂量尼莫地平方式进行治疗;B组采用口服高剂量尼莫地平方式进行治疗;C组采用静脉滴注低剂量尼莫地平方式进行治疗;D组采用静脉滴注中剂量尼莫地平方式进行治疗;E组采用静脉滴注高剂量尼莫地平方式进行治疗。比较5组治疗总有效率、药物不良反应情况、住院总时间、治疗前后MCA血流速度。结果 B、D、E组患者药物治疗总有效率高于A组和C组,差异有统计学意义(P<0.05);B、D、E组患者药物不良反应均少于A组和C组,差异有统计学意义(P<0.05);B、D、E组患者住院总时间短于A组和C组,差异有统计学意义(P<0.05);B、D、E组患者治疗前后MCA血流速度的改善幅度大于A组和C组,差异有统计学意义(P<0.05)。上述观察指标数据B、D、E组中任意两组比较差异无统计学意义,A组和C组比较差异无统计学意义。结论蛛网膜下腔出血后脑血管痉挛患者采用口服大剂量尼莫地平和静脉滴注中高剂量尼莫地平方式进行治疗,可以提高总有效率,减少不良反应,大幅度改善血流速度,缩短住院治疗时间。
Objective To compare and analyze the clinical effect of nimodipine in the treatment of cerebral vasospasm after subarachnoid hemorrhage.Methods 150 patients with cerebral vasospasm after subarachnoid hemorrhage in our hospital from January 2017 to January 2019 were randomly divided into groups A,B,C,D and E,with 30 cases in each group.Group A was treated with oral low-dose nimodi-squared.Group B with oral high-dose nimodi-squared.Group C with intravenous low-dose nimodi-squared.Group D with medium-dose nimodi-squared.Group E was treated with high-dose nimodi-squared intravenous drip.The total effective rate,adverse drug reactions,total hospitalization time and MCA blood flow velocity before and after treatment were compared among the five groups.Results The total effective rate of group B,D and E was higher than that of group A and group C,the difference was statistically significant(P<0.05).The adverse drug reactions of group B,D and E were less than that of group A and group C,the difference was statistically significant(P<0.05).The total hospitalization time of group B,D and E was shorter than that of group A and group C,the difference was statistically significant(P<0.05).The MCA blood flow rate of group B,D and e before and after treatment was significantly lower than that of group A and group C(P<0.05).The degree of improvement was greater than group A and group C,the difference was statistically significant(P<0.05).There was no significant difference between any two groups in group B,D and E in the above indicators,but there was no significant difference between group A and group C.Conclusion Patients with vasospasm after subarachnoid hemorrhage were treated with high-dose nimodipine and high-dose nimodipine in intravenous drip.
作者
解辉
操先红
樊凤
杨克华
Xie Hui;Cao Xianhong;Fan Feng;Yang Kehua(Department of Neurology,Nanchang 334 Hospital,Nanchang,Jiangxi,330024,China;Department of Endocrinology,Nanchang 334 Hospital,Nanchang,Jiangxi,330024,China)
出处
《当代医学》
2020年第35期53-55,共3页
Contemporary Medicine
关键词
蛛网膜下腔出血
脑血管痉挛
尼莫地平
剂量
给药途径
Subarachnoid hemorrhage
Cerebral vasospasm
Nimodipine
Dose
Route of administration
