摘要
目的探讨老年耐药肺结核的结核杆菌的药敏特点方法所有病例均为解放军第309医院2006年3月至2010年10的住院患者,其中28例老年耐药肺结核患者男21例,女7例,平均年龄(67±8)岁,同期随机抽取非老年耐药肺结核患者32例作为对照,其中男23例,女9例,平均年龄(32±8)岁。所有患者痰结核杆菌培养均采用L-J罗氏培养基Bactec-MGIT960快速培养及药敏试验。两组资料结果用SPSS 12.0软件包进行统计学分析结果两组病例耐药药物顺序前四位均为S,H,R,E,老年组耐2～3种药共17例,占60.71%,非老年组共10例,占31.25%;耐3～4种药非老年组共19例,占59.38%,老年组共14例,占50%,老年组以耐2～3种为主,非老年组以耐3～4种药为主,统计学分析差异显著;结果还显示两组药物敏感率均以KOP最高。结论对老年肺结核患者,应加强督导化疗,减少耐药病例的产生。对已耐药的病例,应根据药敏结果选择敏感药物进行化疗;在药敏结果未报之前,可选用包含KOP的方案进行化疗,以提高疗效。
Objective To determine the antimicrobial susceptibility profile of Mycobacterium tuberculosis in elderly patients with drug-resistant pulmonary tuberculosis. Methods The clinical data were compared between elderly patients with pulmonary tuberculosis （elderly group） and non-elderly patients with pulmonary tuberculosis （non-elderly group）. All were admitted to our hospital from March 2006 to October 2010. Elderly group included 21 males and 7 females, with age of （67 ± 8） years. Non-elderly group included 23 males and 9 females, with age of （32 ±8） years. The Mycobacterium tuberculosis were cultured and antimicrobial susceptibility testing were performed in Bactec-MGIT960 system with Lowenstein-Jensen medium. The data were processed by SPSS 12.0 software package. Results The four most commonly resistant drugs in both groups were S, H, R and E sequentially. There were 17 cases （60.71%） resistant to 2 to 3 drugs in elderly group, whereas 10 cases （31.25%） in non-elderly group; and 19 cases （59.38%） resistant to 3 to 4 drugs in elderly group, while 14 cases （50%） in non-elderly group. Resistance to 2 to 3 drugs was predominant in elderly group, while resistance to 3 to 4 drugs in non-elderly group, with significant difference between the two groups. Antimicrobial susceptibility rate of KOP regimen was highest in both groups. Conclusion For elderly patients with pulmonary tuberculosis, the chemotherapy should be under close supervision to avoid the appearance of drug resistant flora. For drug resistant cases, chemotherapeutic drugs should be carefully selected according to the antimicrobial susceptibilty features, and KOP regimen is strongly recommended if the culture test result is not yet available.
出处
《中华老年多器官疾病杂志》
2011年第2期107-109,共3页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
老年人
肺结核
抗药性
分枝杆菌
结核
药物敏感性试验
elderly
pulmonary tuberculosis
drug resistance
mycobacterium tuberculosis
drug sensitivity assay
