摘要
目的了解铜仁市结核病耐药流行状况,评价结核病控制效果,为制定结核病防治对策提供依据。方法收集铜仁市2012年-2013年结核病门诊初治涂阳和复治涂阳患者的痰标本进行分离培养,对分离到的491株结核分枝杆菌菌株进行一线抗结核药物的敏感试验。结果铜仁市结核病患者总耐药率为18.7%,其中初治耐药率为17.8%,复治耐药率为24.3%,耐药谱中链霉素耐药率最高;耐多药率为6.1%,其中初治耐多药率为5.2%,复治耐多药率为11.4%,耐药谱中以异烟肼+利福平+链霉素和异烟肼+利福平+链霉素+乙胺丁醇最为常见;单耐药率为9.0%,耐药谱中链霉素耐药率最高。结论铜仁市结核病耐药率低于全国水平,在进一步实施DOTS策略情况下,仍需进一步加强耐药结核病的防治工作。
Objective To investigate the current status of drug- resistance of tuberculosis（ TB） in Tongren and evaluate the control effect on pulmonary tuberculosis,so as to provide evidence for TB control policy. Methods To collect all new smear positive cases,and retreatment smear positive cases in survey area were the cases for surveillance during 2012- 2013. All of491 isolated strains of Mycobacterium tuberculosis were tested for the first line drug susceptibility. Results The over tall drug-resistance was 18. 7%,the primary resistance was 17. 8%,and the acquired drug resistance was 24. 3%,strepomycin was with the highest drug resistance rates of resistance spectrum; the muli- drug resistance rate was 6. 1%,the primary muli- drug and acquired drug resistance rate was 5. 2% and 11. 4%. Resistance to isoniazid ＋ rifampicin ＋ streptomy or isoniazid ＋ rifampicin ＋streptomycin ＋ ethambutol was the most common. The single drug resistance rate was 9. 0%,streptomy with the highest resistance rates. Conclusion The prevalence of drug resistance of tuberculosis in Tongren city was lower than the average national level,suggesting in the further implementation of DOTS strategy,to further strengthen the prevention and control of drug resistant tuberculosis.
出处
《中国卫生检验杂志》
CAS
2016年第6期855-857,862,共4页
Chinese Journal of Health Laboratory Technology
基金
贵州省卫生计生委科学技术基金项目(gzwkj2012-1-115)
关键词
结核病
耐药性
监测
Tuberculosis
Drug resistance
Surveillance
