摘要
目的探讨分子生物学信息反馈机制对耐碳青霉烯类鲍氏不动杆菌(CRAB)感染预防控制的效果,为寻找更为有效的预防控制方式提供实践基础。方法应用DNA指纹图谱技术(ERIC-PCR)分析RICU CRAB聚集病例,并将数据分析结果反馈给RICU,结合手卫生、环境清洁消毒、隔离患者等综合措施进行干预,采用每月CRAB感染/定植密度和手卫生消耗液的变化为指标,观察循证医学信息反馈机制对CRAB感染干预的长期效果,并与既往的干预方式进行比较。结果应用邮件反馈和现场督导检查结合综合干预的效果维持时间较短,常有反复;应用分子生物学分析数据反馈结合综合性干预后,RICU的感染/定植密度由25例次/千个住院日下降到平均5例次/千个住院日,最低降至0,效果持久。结论以分子生物学分析手段实施的循证医学反馈机制提高了医护人员预防控制医院感染的认识,结合综合性干预措施可以持久而有效的降低RICU CRAB感染/定植密度。
OBJECTIVE To explore the effect of evidence based molecular biological information feedback on carbapenem-resistant Acinetobacter baumannii infections,to provide the practical base for effective preventing and control CRAB infections.METHODS The ERIC-PCR was performed to judge the relateness of CRABs.The outcome of data was feedback to RICU ward,at the same time,the comprehensive intervention measures were taken.The CRAB infection/colonization density and the consumption of hand hygiene were observed monthly.RESULTS The effect on CRAB infections lasted short and repeatedly often by conventional mail and living method.By evidence based data feedback,the CRAB infection/colonization density descended from 25 cases to 4 cases,with the minimum 0 day.CONCLUSIONS The effect on CRAB infections,through data feekfack based molecular biological analysis,was longer lasting and more stable.The strengthening for management of respiroty and hand hygiene were crucial for the intervention effect.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第12期2432-2434,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
耐碳青霉烯类抗菌药物
医院感染
预防控制效果
Acinetobacter baumannii
Carbapenem-resistant antibiotics
Nosocomial infection
Effect of prevention and control
