摘要
目的：初步探讨口腔颌面部恶性肿瘤患者免疫抑制的原因。方法：检测患者外周血淋巴细胞亚群及体外淋巴细胞增殖水平。结果：患者的ＣＤ４＋ Ｔ细胞数量增多，但对ＰＨＡ和ＳＥＢ刺激的反应性均低于正常人。在ＰＨＡ刺激下，恶性肿瘤患者组ＣＤ４＋ Ｔ细胞百分含量呈下降趋势。结论：患者外周血中ＣＤ４＋ Ｔ细胞表面受体的ｖβ部分可能存在缺陷。
Objective:To determine if there is any defect of CD4 + T lymphocyte in the peripheral blood of patients with oral and maxillofacial malignant tumors. Methods:Use MTT dying and flow cytometry assay to identify the lymphocyte stimulation response to PHA or SEB, and the percent of T subset in the peripheral blood of these patients. Results:The percent of CD4 + T cell and the ratio of CD4/CD8 in patient group were both higher than those in health group. The response of lymphocyte in patients′ peripheral blood to PHA and SEB was lower than that in health group. Conclusion:The immune response of patients with oral and maxillofacial malignant tumors is lower than that of the healthy. There may be some defects on the vβ chain of TCR on CD4 + T cell in peripheral blood of these patients.
出处
《军医进修学院学报》
CAS
1999年第4期275-277,共3页
Academic Journal of Pla Postgraduate Medical School
