摘要
目的寻找建立大鼠肝大部分切除术模型时合适的麻醉剂和麻醉方法。方法将75只大鼠随机平均分成A、B、C3组，分别为乙醚组、水合氯醛组、戊巴比妥钠组。观察大鼠麻醉诱导时间、术后苏醒时间和死亡率。结果A、B、C3组的麻醉诱导时间分别为（4．11±0．65）、（13．02±0．61）、（10．13±0．48）min，差异有统计学意义（P〈0．01）；术后苏醒时间分别是（22．12±5．23）、（167．09±4．52）、（93．26±3．56）min，差异有统计学意义（P〈0．01），3组的死亡率分别是8％、40％、32％，A组与B组差异有统计学意义（P〈0．01），而它们与C组比较差异无统计学意义（P〉0．05）。结论建立大鼠大部分肝切除模型时，采用乙醚麻醉时诱导时间短、术后苏醒时间短、术后死亡率低，是较为合适的麻醉方法。
Objective To find appropriate anesthetics and anesthetic methods on major hepatectomy in rats. Methods Seventy-five rats were randomly divided into the following three groups： ether inhalation group （ group A, n = 25 ）, chloral hydrate intraperitoneal injection group （ group B, n = 25 ） and sodi- um pentobarbital intraperitoneal injection group （group C, n = 25 ）. The following parameters were evaluated ： time of induction of anesthesia, time of postoperative waking and mortality rate after hepatectomy. Re- sults The time of induction of anesthesia in groups A, B, C was respectively （4. 11 ± 0. 65 ） , （ 13.02 ± 0. 61 ）, （ 10. 13 ±0. 48） min （P 〈0. 01 ）. Postoperative waking time after major hepatectomy in groups A, B, C was respectively （22. 12 ±5.23）, （ 167. 09 ±4. 52）, （93.26 ±3.56） min （P 〈0. 01 ）. The mortality rate in groups A, B, C was 8% , 40% , 32% respectively, and there was significant difference between groups A and B （ P 〈 0. 01 ）. Conclusion It is a satisfactory way to use ether for anaesthesia to build major hcpatectomy model in rats because of the shorter time of induction of anesthesia and the time of postoperative waking, and the lower postoperative mortality rate.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2011年第6期932-934,共3页
Chinese Journal of Experimental Surgery
关键词
大鼠
肝切除术
乙醚
水合氯醛
戊巴比妥钠
麻醉
Rat
Hcpatectomy
Ether
Chloral hydrate
Sodium pentobarbital
Anaesthesia
