摘要
目的 通过对血清p53抗体与化疗敏感性及预后的关系的研究,探讨血清p53 抗体在肺癌中的临床意义.方法 对57例初步诊断为肺癌的患者应用ELISA 法检测血清p53 抗体滴度,经酶联免疫检测仪测吸光值E450,计算抗体指数,进行统计学分析.结果 57例中阳性25 例,阳性率为43.9 %.血清p53 抗体水平与肺癌的病理类型、分期、分化和淋巴结转移有关,与肺癌的预后有关.结论 p53 抗体的产生可能是肺癌发生的早期指征,化疗前测定血清p53抗体可以预测化疗疗效,可以预测肺癌的预后.
Objective To identify correlation of serum p53 antibody and chemosensitivity and prognosis to determine its effect to lung cancer. Methods 57 patients with lung cancer were applied with ELISA method to test p53 antibodies and the absorbanee E450 measured with a micro plate reader. Then the p53 antibody index was calculated and statistical analyses were performed. Results 25 cases reflected positive, 43.9%, which demonstrated that p53 antibody level was correlated with the histological type, degree of differentiated tumors and TNM stage, as well as its prognosis. Conclusion It suggests that the production of p53 antibody be an early indicator of lung cancer. The indicator could help foresee effectiveness level of chemotherapy as well as the prognosis.
出处
《中国急救复苏与灾害医学杂志》
2011年第5期417-420,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
