摘要
目的 :探讨肺癌患者测定血清p5 3抗体的临床意义。方法 :采用ELISA法检测 12 0例肺癌患者术前血清p5 3抗体 ,并以 30例肺部良性疾病患者和 12 0例正常健康人作对照。结果 :(1)肺癌患者血清p5 3抗体水平和阳性率均明显高于肺部良性疾病患者和正常人 (P <0 0 5 )而正常人与肺部良性疾病患者间无显著差异 (P >0 0 5 )。 (2 )肺癌患者血清p5 3抗体水平和阳性率均与肺癌细胞分化程度和病期有密切关系 (P <0 0 1或P <0 0 5 )。结论 :检测血清p5 3抗体有助于肺部良恶性疾病的诊断 ;术前测定有助于判断肺癌进展和分期。
Objective:To explore the clinical significance in detect ing serum p53 antbodies in patients with lung cancer.methods:One hundred and twenty patients with lung cancer were tested for p53 antibodi es by enzyme linke d immunosorbent assay(ELISA).Moreover,30 patient with benign pulmonary disease a nd 120 healthy individuals were recruited as controls.resuits:(1) The level and positive rate of serum p53 antbodies in patients with lung cancer were significantly higher than those in patients with benign pulmonary diseases and normal individuals( P <0 05),but there was no significant difference between patients with benign pulmonary diseases and normal individuals( P >0 0 5).(2)The level and positive rate of pre-operative serum p53 antibodies in patients with lung cancer were closely related to cell differentiation and stage of lung cancer( P <0 01 or P <0 05).Conclusion:Detection of serun p53 antbodies is helpful in the diagnosis of benign or malignant pulmonary diseases,an d estimation of the devlepment or stage,of lung cancers.
出处
《华西医学》
CAS
2002年第1期23-24,共2页
West China Medical Journal
基金
国家自然科学基金资助(391 70 80 8)
