摘要
目的:研究TGF-β1基因(转化因子-β1)启动子序列509C/T的多态性与妊娠期高血压病(妊高征)的关系。方法:应用聚合酶链反应-限制性片段长度多态性技术检测我院2010年1～12月100例妊高征患者与100例正常妊娠妇女的TGF-β1基因多态性,比较两组人群TGF-β1基因型和等位基因分布频率是否存在统计学差异。结果:在妊高征组患者中CC基因型占48%、CT基因型占31%、TT基因型占69%;在正常孕妇中CC基因型占15%、CT基因型占10%、TT基因型占27%。两组的基因型及等位基因分布差异有统计学意义(P<0.05)。结论:TGFβ1-509 C/T基因多态性与妊娠高血压综合征的发病有明显相关性。
Objective：To study TGF-β1 gene（transforming growth factor-β1） promoter sequence 509 C/T polymorphism is associated with gestational hypertension（pregnancy induced hypertension） and relationship.Methods：Polymerase chain reaction-restriction fragment length polymorphism detected in our hospital from January to December 2010 100 cases of pregnancy hypertension patients and 100 normal pregnant women,TGF-β1 gene polymorphism,compared two groups TGF-β1 genotype and allele frequency of the existence of significant differences.Results：The pregnancy hypertension in patients with CC genotype group accounted for 48%,CT genotype accounted for 31%,TT genotype was 69%;CC genotype in the normal pregnant women accounted for 15%,CT genotype accounted for 10%,TT genotype 27%.The genotype and allele distribution of the two groups showed significantly different（P0.05）.Conclusion：According to my research shows that hospital,TGF β1-509 C/T polymorphism and the incidence of pregnancy induced hypertension significantly correlated.
出处
《中国医药导报》
CAS
2011年第15期43-44,共2页
China Medical Herald
