摘要
目的:研究转化生长因子-β1(TGF-β1)基因-509C/T位点多态性在广西壮族与汉族人群中的分布。方法:应用聚合酶链反应-限制性片段长度多态性技术(PCR—RFLP)检测180名壮族人和170名汉族人的TG-β1基因-509C/T位点多态性,比较两组人群TGFβ1基因型和等位基因的分布频率。结果:在壮族人中CC基因型占41.1%、CT基因型占46.1%、TT基因型占12.8%;在汉族人中CC基因型占28.9%、CT基因型占52.9%、TT基因型占18.2%。两组人群TGF-β1基因型的分布频率差异有显著性。结论:壮族与汉族人群TGF-β1基因多态性分布频率差异有显著性。
To study the distribution of transforming growth factor-β1 （TGF-β1） gene polymorphism at position-509C/T between the Chinese Zhuang and Han ethnic groups in Guangxi province. Methods： TGF-β1 gene polymorphism at position-509C/T was detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） in Zhuang （n= 180） and Hans （n= 170）; the genotype and allele frequencies were calculated and compared. Results： The frequencies of CC, CT and TT genotypes were 41.1%, 46. 1% and 12.8% in the Zhuang nationality, and 28. 9%, 52.9% and 18. 2% in the Hans, respectively. A significant difference was found in the frequency distribution of TGF-β1 genotype between the Zhuang and the Han nationality. Conclusion： There is significant difference of TGF-β1 gene polymorphism between the Zhuang and Han nationality.
出处
《解剖学杂志》
CAS
CSCD
北大核心
2005年第4期379-380,407,共3页
Chinese Journal of Anatomy
基金
广西教育厅基金资助项目(桂科教200420)
