摘要
目的研究5-甲基四氢叶酸-高半胱氨酸甲基转移酶(5-methyltetrahydrofolate-homocysteine methyltransferase,MTR)SNPs位点Rs1805087多态性与非综合征性唇腭裂的关系。方法采用聚合酶链反应-限制性片段长度多态性方法,检测174例非综合征性唇腭裂患者和169例正常对照组的MTR基因Rs1805087的多态性。结果 MTR基因Rs1805087位点基因型频率分布符合Hardy-Weinberg平衡;MTR基因Rs1805087位点基因型及等位基因的分布在NSCL/P组与对照组之间均无统计学意义(P>0.05)。结论结果未显示MTR基因Rs1805087多态性与非综合征性唇腭裂的发生有关。
Objective To investigate the association of the Rs1805087 polymorphisms of the 5-methyltetrahydrofolate-homocysteine methyltransferase（MTR）gene with non-syndromic cleft lip with or without cleft palate（NSCL/P）.Methods The Rs1805087 polymorphisms of MTR gene was examined by PCR-RFLP in 174 patients and the 169 controls.Results The genotypic distribution of Rs1805087 was not deviated from the Hardy-Weinberg equilibrium.There was no significant difference in genotype and allele frequencies for MTR Rs1805087 variants between patients and healthy individuals（P0.05）.Conclusion The Rs1805087 polymorphism of MTR gene was not associated with NSCL/P in Chinese.
出处
《北京口腔医学》
CAS
2011年第2期88-91,共4页
Beijing Journal of Stomatology
