摘要
多梳基因(PcG)在胚胎发育、细胞周期调节、造血干细胞更新、肿瘤发生中起重要作用。转录抑制因子Bmi-1是PcG家族成员之一,与多种人类恶性肿瘤的发生、发展有关。最新研究发现Bmi-1高表达与胃癌的发生、发展、浸润、转移、预后等密切相关。本文就Bmi-1的分子结构、作用机制及其与胃癌关系的研究进展作一综述。
Polycomb group gene （PcG） play a crucial role in regulation of embryonic development, cell cycle, selfrenewal of hematopoietic stem cells and tumor genesis. Bmi-1, which is a transcription repressor, is a member of PcG family. It was found to be related with the genesis and development of several human malignancies. Recent studies have shown that overexpression of Bmi-1 was correlated with the genesis, development, invasion, metastasis and prognosis of gastric cancer. This article reviewed the molecular structure and mechanism of action of Bmi-1, and its relationship with gastric cancer.
出处
《胃肠病学》
2011年第3期178-180,共3页
Chinese Journal of Gastroenterology
关键词
胃肿瘤
多梳基因
癌基因
分子结构
Stomach Neoplasms
Polycomb Group Genes
Oncogenes
Molecular Structure
