摘要
目的：观察茵陈蒿合承气汤对急腹症时内毒素血症的影响。方法：选择具有内毒素血症的３０例急腹症患者，随机分为常规组和中西组，每组１５ 例。常规组给予抗感染补液治疗，中西组除常规治疗外，并给予茵陈蒿合承气汤口服。定量测定外周血内毒素（ＥＴ） 、肿瘤坏死因子α（ＴＮＦα） 、血栓素Ｂ２（ＴＳＢ２）／６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１ α） 的水平，并观察每日大便次数的变化。结果：两组患者入院时外周血ＥＴ含量分别为９１．３０ ±３９．５０ ｐｇ／ｍｌ、８９．２１ ±２８．９０ ｐｇ／ｍｌ（ Ｐ＞ ０．０５） ，均明显高于正常对照组３３．２４ ±１０．８４ ｐｇ／ｍｌ（ Ｐ＜ ０．０１） 。两组患者外周血ＴＮＦα、ＴＸＢ２／６ｋｅｔｏＰＧＦ１α值明显高于正常人（ Ｐ＜０．０１） ，每日大便次数则明显少于正常人（ Ｐ＜ ０．０１） 。接受治疗后，中西组在降低外周血ＥＴ、ＴＸＢ２／６ｋｅｔｏＰＧＦ１α、ＴＮＦα含量和促进肠道功能恢复方面明显优于常规组。结论：茵陈蒿合承气汤通过通里攻下、清热解毒能降低急腹症患者外周血内毒素含量，减少内毒素血症的发生，抑制炎症介质的产生，维持机体内环境稳定，从而改善预后。
To investigate the effect of Yin Chen Hao He Cheng Qi decoction on endotoxemia in acute abdomen Methods:A prospective and randomized study was performed on 30 patients with acute abdomen with endotoximia.Among them 15 patients were given oral Yin Chen Hao He Cheng Qi decoction combined with general therapy(Y+G)and the other 15 patients were treated with the general therapy (G) only.The levels of plasma endotoxin(ET),serum TNFα as well as thromboxan B 2 (TXB 2) and 6-keto-prostagladin F 1α(6-keto-PGF 1α) were measured during 7 dyas after admission.Results:The levels of plasma endotoxin in all patients were much higher than normal on admission (P<0 01) .The effects of Y+G were better than G only:decreasing the levels of plasma endotoxin,improving gastrointestinal function.Conclusion:The mechanism of Y+G in reducing plasma endotoxin level may be through reducing endotoxin absorption,promoting intestinal peristalsis and enhancing bowel movements.It is suggested that Yin Chen Hao He Cheng Qi decoction combined with general therapy is an effective method for endotoxemia in acute abdomen and may improve the prognosis.
出处
《中国中西医结合外科杂志》
CAS
1999年第5期276-280,共5页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
