摘要
本文对急性出血坏死性胰腺炎（ＡＨＮＰ）时的内毒素血症（ＥＴＭ）进行实验研究和临床观察。研究中应用Ｗｉｓｔａｒ大鼠５个系列２ｌ４只，观察了２４例急性胰腺炎病人，并应用茵陈蒿承气汤（合方）对急性胰腺炎时的ＥＴＭ进行防治。结果发现，实验性ＡＨＮＰ血浆内在素（ＥＴ）含量随致病原浓度加大而升高，相同浓度致病后ＥＴ含量到４８小时达到高峰，ＥＴ含量高则病情重死亡率高；合方可使ＥＴ含量下降，防治组和治疗组的死亡卒分别为１８．２％和２８．１％，明显低于对照组的５３．３％；临床观察到同样的疗效。合方具有维持肠血屏障和胆血屏障的作用，能够提高机体免疫力、拮抗和清除ＥＴ等，从而发挥其法邪扶正之功效，深入阐明了中西医结合是防治急性胰腺炎的有效手段。
series of experimental studies and clinical observations on cndotoxemia in acute hemor-rhagic necrotizing pancratitis(AHNP)have been carried out in 214 Wistar rats and 24 patienswith acute pancreatitis(AP),and the role of Yin Chen Hao Cheng Qi Decoction(YCHCQD,茵蒿承气汤)on endotoxemia in AP was investigated。The results showed that the concentration of endotoxin was increased with the increasingconcentration of the pathogenic substance and reached the peak level at 48h in the condition ofthe same concentration of the pathogenic substance ,the mortality of AHNP in rats was increasedwith the increasing concentration of endotoxin, The mortality was reduced in prevention-treat-ment group (18.2%)and treatment group(28.1%)compared with control group(53.3%), andso was the concentration of endotoxin.The results suggested that YCHCQD could maintain thefunction of the Gut-blood barrier and bile-blood barrier,enhance the body immunity ,reducethe absorption of endotoxin from the Gut and eliminate it.The therapy of traditional and westernmedicine(ITCWM) is an effctive method fot prevention and treatment of AP.
出处
《中国中西医结合外科杂志》
CAS
1995年第3期136-140,共5页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
急性
胰腺炎
内毒素血症
茵陈蒿合承气汤
防治
acute hemorrhagic necrotizing panceratitis (AHNP)
endotoxemin
Yin Chen hao Cheng Qi Decoction
