摘要
Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the treated groups, the rats were treat ed with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly ( P <0.0 5), while the endotoxin level in stool was obviously higher than that in the unt reated model group.Conclusion:DCQG has the intestinal barrier protective e ffect including anti-bacteria, anti-inflammation and clearing endotoxin.
Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the treated groups, the rats were treat ed with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly ( P <0.0 5), while the endotoxin level in stool was obviously higher than that in the unt reated model group.Conclusion:DCQG has the intestinal barrier protective e ffect including anti-bacteria, anti-inflammation and clearing endotoxin.
基金
DepartmentofPharmacology
TianjinMedicalUniversity
Tianjin(30 0 0 70)
China
