摘要
目的观察通心络胶囊对老年睡眠期陈-施呼吸(CSR)患者的影响。方法根据多导睡眠图监测(PSG)结果,除外心力哀竭病因者,入选老年睡眠期CSR患者30例,按呼吸暂停低通气指数分为轻度(n=11)、中度(n=9)及重度(n=10)CSR组,均予口服通心络胶囊2粒/次,3次/d,共30d。分析治疗前后PSG指标及症状的变化及与日间嗜睡程度的相关关系。日间嗜睡程度以Epworth嗜睡评分(ESS)评定。结果通心络胶囊治疗前后比较显示,3组中仅重度组呼吸暂停低通气指数显著降低[(37.4±4.3)vs(30.8±4.5),P<0 05];3组的日间ESS均有改善(P<0.05),轻度组由(8.8±20)降低到(6.0±1.9),中度组由(10.7±2.1)降至(8.0±2.3),重度组由(13.4±2.4)降至(10.2±3.0)。相关性分析显示轻度组Ess与微觉醒指数呈正相关(r=0.775,P<0.05),而中重度组日间嗜睡评分与最低血氧饱和度呈负相关(分别为r=-0.751,P<0.05;r=-0.739,P<0.05)。结论通心络胶囊可改善老年睡眠期CSR者的日间嗜睡症状,可能部分降低重度老年睡眠期CSR的呼吸暂停低通气指数。
Objective To observe the effects of Tongxinluo capsules on the elderly patients with Cheyne-Stoke respiration （CSR） during sleep. Methods According to the results of polysomnography, 30 elderly patients with nocturnal CSR but without heart failure were recruited and divided into mild （n=ll）, moderate （n=9） and severe （n=10） CSR groups. Tongxinluo was used at the dosage of 2 capsules each time, three times a day for successive 30 days. Epworth sleepiness score （ESS）, polysomnographic parameters, and clinical features were compared before and after the treatment. Their correlation with daytime sleepiness was analyzed. Results Apnea-hypopnea index（AHI） was statistically decreased after treatment only in severe CSR group [（37.4±4.3） vs （30.8±4.5）, P〈0.05]. ESS showed a significant improvement in all groups [（8.8±2.0） vs （6.0±1.9） in mild CSR group; （10.7±2.1） vs （8.0±2.3） in moderate CSR group and （13.4±2.4） vs （10.2±3.0） in severe CSR group, P〈0.05]. Correlation analysis demonstrated that the ESS was positively correlated with arousal index in mild CSR group（r =0.775, P〈0.05）, and negatively correlated with the mininal oxygen saturation in moderate and severe CSR groups （r = -0.751, -0.739 respectively, P〈0.05）. Conclusions Tongxinluo capsules could alleviate excessive daytime sleepiness in the elderly with CSR during sleep, and might partially reduce the AHI in the elderly with severe CSR.
出处
《中华老年多器官疾病杂志》
2011年第1期25-28,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
老年人
陈-施呼吸
日间嗜睡
通心络
aged
Cheyne Stoke respiration
excessive daytime sleepiness
Tongxinluo
