摘要
目的探讨丹参素对博莱霉素致大鼠肺纤维化的治疗作用及可能作用机制。方法采用气管内注入博莱霉素5 mg/kg致大鼠肺间质纤维化的造模方法,将40只大鼠随机分为正常组、模型组、地塞米松组、丹参素组,并分别给药。各组动物于饲养28 d后处死取材,行肺组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)及羟脯氨酸(HYP)含量测定,以观察丹参素对肺纤维化形成的影响。结果与正常组比较,丹参素组肺组织SOD活性显著增加,MDA、HYP含量显著减少(P均<0.05);丹参素治疗组与地塞米松治疗组之间比较差异无统计学意义(P>0.05)。结论丹参素能够抑制或延缓博莱霉素致大鼠肺纤维化的发生和发展。
Objective To study the preventive and therapeutic effect of tanshinol on bleocin-induced pulmonary fibrosis in rats and possible mechanism. Methods Forty male rats were assigned randomly into four groups： normal group, model group, tanshinol group, dexamethasone group with 10 rats in each group. The pulmonary fibrosis rat models were founded by infusing 5 mg/kg bleocin into trachea. All rats were killed when feeding for 28 days. The SOD, MDA and HYP contents in lung tissue were assayed in order to observe the influence of Tanshinol on pulmonary fibrosis. Results SOD activity of lung tissue was significantly higher, and lower MDA, HYP contents in tanshinol group than that in the normal group. There was no statistical difference between tanshinol group and dexamethasone group. Conclusion Tanshinol can relieve and inhibit pulmonary fibrosis of rats induced by bleoein.
出处
《山东医药》
CAS
北大核心
2011年第13期24-25,共2页
Shandong Medical Journal
基金
山东省自然科学基金项目(Y2007C162)
