摘要
采用结扎大鼠左冠脉前降支造成急性心肌缺血模型,本文首次报道了复方丹参对急性缺血心肌磷脂肌醇代谢的影响。结果显示:急性缺血10 min,心肌磷脂肌醇信息传递系统功能增强,其磷脂酰肌醇-4,5-二磷酸(PIP_2)和肌醇-1,4,5-三磷酸(IP_3)水平明显高于非缺血对照组(P<0.01,n=7)。复方丹参(2g/kg体重)能显著抑制急性缺血导致的心肌PIP_2和IP_3水平的升高,其PIP_2和IP_3水平显著低于缺血组(P<0.01,n=7)
The effects of Salvia miltiorrhizae compositae (SMC) on phosphoinositides metabolism of acutemyocardial ischemia in rats were studied. The results showed that the function of the phos-phoinositide signaling system was enhanced 10 min. after acute myocardial ischemia. Both of theaccumulations of phosphatidylinositol-4,5-biphosphate (PIP_2) and inositol-1,4,5-triphosphate (IP_3)were higher than, those of the non-ischemic control group (P<0.01, n=7). The rise of the levels ofPIP_2 and IP_3 caused by acute myocardial ischemia was remarkablely inhibited by the SMC (2g/kgbody wt.), and the levels of PIP_2 and IP_3 were lower than those of the ischemic group (P<0.01, n=7).
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1993年第6期354-355,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
心肌缺血
复方丹参
磷脂肌醇
代谢
myocardium
ischemia
phosphatidylinositol-4
5-biphosphate
inositol-1
4
5-triphosphate
salvia miltiorrhizae
