摘要
以１ ，３环己二酮为起始原料，形成单苯腙后，经过环合、甲基化得９甲基１ ，２ ，３ ，９四氢４ Ｈ咔唑４酮（３） ，与吗啉及多聚甲醛进行 Ｍａｎｎｉｃｈ 反应，再与２甲基咪唑反应、成盐得标题化合物，总收率为４９１ ％ 。
An improved process for the preparation of ondansetron hydrochloride (1) is described . Compound 1 wassynthesized from 1 ,2 ,3 ,9 tetrahydro 9 methyl 4 H carbazol 4 one(3) by Mannich reaction and condensation with 2 methylimidazole . The compound 3 was prepared from 1 , 3 cyclohexanedione through formation ofmonophenylhydrazone ,cyclization and methylation . The overall yield was 49 .1 % . The physical constants and spectradata of the title compound and that of some intermediate have been reported .
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1999年第4期246-248,共3页
Journal of China Pharmaceutical University
关键词
昂丹司琼
MANNICH反应
合成
合成
止吐药
H T3 antagonists
Ondansetron hydrochloride
Mannich reaction
1 ,2 ,3 ,9 Tetrahydro 4 H carbazol 4 one derivatives
