摘要
目的观察原发性高血压(EH)合并糖耐量减低(IGT)患者血浆氧化应激水平变化,探讨EH、IGT及EH合并IGT与氧化应激的关系。方法入选EH患者82例,其中合并IGT者42例,糖耐量正常(NGT)者40例;非EH者80例,其中IGT者40例,NGT者40例。采用生化法测定血浆中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)和丙二醛(MDA)的水平。结果 MDA水平:EH+IGT组明显高于非EH+IGT组[(22.37±1.28)比(18.21±1.75)μmol/L;]GSH水平:EH+IGT组明显低于非EH+IGT组[(0.16±0.03)比(0.19±0.04)μmol/L;]SOD水平:EH+IGT组明显低于非EH+IGT组[(54.31±6.26)比(60.56±9.18)U/ml]。在82例IGT患者中,MDA与收缩压、舒张压、餐后2 h血糖(2 hPG)、胰岛素抵抗指数(HOMA-IR)、体质指数(BMI)呈正相关,SOD与收缩压、舒张压、2 hPG呈负相关;GSH与收缩压负相关,与空腹血糖、2 hPG、HOMA-IR、BMI呈正相关。在80例NGT患者中,MDA与收缩压、舒张压、空腹血糖、HOMA-IR、BMI呈正相关,SOD与收缩压、舒张压呈负相关,与空腹血糖呈正相关;GSH与收缩压、舒张压呈负相关,与空腹血糖、HOMA-IR、BMI呈正相关。多因素Logistic回归分析显示:EH合并IGT与MDA、GSH、SOD、空腹血糖、2 hPG、BMI、收缩压、舒张压呈正相关(β为0.064、-0.127、-0.630、0.098、1.674、0.142、0.247、0.074;P<0.05)。结论 EH、IGT及EH合并IGT患者血浆MDA水平增高,GSH、SOD水平降低,提示EH和IGT患者体内氧化应激反应增强;EH;IGT患者体内氧化应激反应进一步增强。
Objective To study the levels of serum glutathione peroxidase（GSH-PX）,superoxide dismutase（SOD） and malonyldialdehyde（MDA） in patients with essential hypertension（EH） complicated by impaired glucose tolerance（IGT） so as to investigate the relationships of lipid peroxidation with EH,IGT,and EH with IGT. Methods Totally 82 EH patients in whom 40 with normal glucose tolerance（NGT） and 42 with IGT,and 80 non-EH patients in whom 40 with NGT and 40 with IGT were recruited.The levels of GSH-PX,SOD and MDA were measured by using chemically colorimetric method. Results MDA levels（μmol/L） were higher in EH ＋ IGT group than in non-EH ＋ IGT group（22.37 ±1.28 vs 18.21±1.75）,GSH levels（μmol/L） were lower in EH ＋ IGT group than in non-EH ＋ IGT group（0.16 ±0.03 vs 0.19±0.04）,SOD levels（U/mL） were lower in EH ＋ IGT group than in non-EH ＋ IGT group（54.31 ±6.26 vs 60.56±9.18）.And in all the 82 IGT patients,MDA level was positively correlated with the levels of systolic blood pressure（SBP）,diastolic blood pressure（DBF）,2-h postprandial blood glucose（2hPG）,HOMA insulin resistance index（HOMA-IR）,and body mass index（BMI）;SOD level was negatively correlated with levels of SBP,DBF,and 2hPG;and glutathione（GSH） level was negatively correlated with the SBP level,and positively with the levels of fasting plasma glucose（FPG）,2hPG,HOMA-IR,and BMI.In all the 80 IGT patients,MDA level was positively correlated with the levels of SBP,DBF,FPG,HOMA-IR,and BMI;SOD level was negatively correlated with SBP and DBP,and positively with FPG level;and GSH level was negatively correlated with the levels of SBP and DBP,and positively with the levels of FPG,HOMA-IR,and BMI.Multivariate Logistic analysis showed that EH complicated by IGT was positively correlated with MDA,GSH,SOD,FPG,2hPG,BMI,SBP and DBP（β=0.064,-0.127,-0.630,0.098,1.674,0.142,0.247,0.074,respectively,P0.05）. Conclusion In patients with EH,IGT,and EH complicated by IGT.the serum level of MDA
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第7期728-731,共4页
Chinese General Practice
