摘要
目的 研究几丁糖薄膜对肌腱粘连和愈合的影响,为临床应用几丁糖薄膜预防肌腱术后粘连提供实验依据。方法 以55 只6～8 个月来亨鸡的趾深屈肌腱为实验模型,将切断的趾深屈肌腱周围包裹几丁糖薄膜,术后2、4、6、8和10 周分别测量肌腱的活动或抗张强度,肉眼及病理切片观察肌腱的粘连、愈合情况。结果 几丁糖薄膜能有效预防肌腱粘连,早期(即4 周内)可以影响肌腱愈合,4 周后可加快肌腱愈合和增加肌腱抗张强度。结论 几丁糖薄膜具有无毒副作用、生物通透性好及生物降解、吸收好,并可以选择性抑制成纤维细胞生长等优点,能有效预防肌腱粘连,晚期(4 周后)可加快肌腱愈合。
Objective To investigate the effects of chitosan membrane on tendon adhesion and healing and obtain experimental data for clinical use in preventing postoperative tendon adhesion.Methods The long flexor tendon of 55 adult legborn hens were cut and sutured encapsulated by chitosan membrane. Movement and anti tension capability of tendon were assessed at 2,4,6,8 and 10 weeks after operation by SWD 10 type tendon stretcher. Tendon healing and adhesion were observed with light microscope.Results Tendon healing could be effected by chitosan membrane within 4 weeks, and tendon anti tension strength was increased after 4 weeks.Conculsion Chitiosan membrane possesses the following characteristics:no side effects, good permeability, resolvable, absorbable and selective inhibition the growth of fibroblast. It is a desirable biological material to prevent tendon adhesion.
出处
《中国修复重建外科杂志》
CAS
CSCD
1999年第6期382-385,共4页
Chinese Journal of Reparative and Reconstructive Surgery
