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Foxp3结构、功能及其在机体免疫抑制中的作用 被引量：1

MOLECULAR STRUCTURE AND FUNCTION OF FOXP3 AND ITS MECHANISM OF IMMUNOSUPPRESSION
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摘要 Foxp3特异性表达于胸腺、脾脏和淋巴结等淋巴器官和组织中的CD4+CD25+调节性T细胞(regulatory T cells,Treg)表面,在诱导CD4+CD25+Treg发育、分化与功能发挥中起重要的作用,它通过调控Treg的转录和蛋白表达参与机体稳态机体,在感染免疫、肿瘤免疫及自身免疫病中发挥重要作用。本文就Foxp3分子结构、功能及其在免疫抑制中的作用机制作一综述。 Foxp3 is located in the X chromosome,belonging to a new member of the Forkhead/winged helix family that regulates the activation and expression of the target genes by the link of the forkhead domain and DNA specific sites.Foxp3 is specifically expressed on the surface of CD4＋CD25＋Treg in the thymus,spleen,lymph nodes,lymphoid organs and other tissues.Foxp3 is a master control factor for the infection,tumor immunity and autoimmunity through regulating Treg transcription and protein expression.This review summarizes molecular structure and function of Foxp3 and its mechanism of immunosuppression.
作者 董林 王艳萍 王金良 沈志强 谢金文
机构地区 山东省滨州畜牧兽医研究院 山东绿都生物科技有限公司
出处 《中国动物传染病学报》 CAS 2010年第6期74-78,共5页 Chinese Journal of Animal Infectious Diseases
基金 山东省自然科学基金项目(2010ZRA16005)
关键词 FOXP3 调节性T细胞 免疫抑制 Foxp3 regulatory T cells（Treg） immunosuppressive
分类号 Q754 [生物学—分子生物学]
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参考文献27

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共引文献12

同被引文献41

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二级引证文献6

中国动物传染病学报
2010年 第6期

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