摘要
目的探讨磷酸化的哺乳动物雷帕霉素靶蛋白(p-mTOR)在卵巢上皮癌组织中的表达和临床意义。方法采用免疫组化方法检测154例卵巢上皮癌、25例良性上皮瘤和34正常卵巢组织中p-mTOR蛋白表达情况,并分析其与卵巢上皮癌临床病理特征的关系。结果 p-mTOR在卵巢上皮癌组织阳性表达率为53.90%(83/154),在正常卵巢和良性卵巢上皮瘤组织中表达缺失。其中卵巢浆液性囊腺癌、粘液性囊腺癌、内膜样腺癌患者组织中的p-mTOR蛋白阳性表达率依次为54.78%、58.33%、40%(P>0.05)。卵巢上皮癌Ⅰ～Ⅱ期和Ⅲ～Ⅳ期患者中p-mTOR蛋白阳性表达率分别为23.08%和56.03%(P<0.05)。在卵巢上皮癌高、中分化和低分化患者组织中,p-mTOR蛋白阳性表达率分别为53.95%和53.85%,(P>0.05)。结论 p-mTOR在卵巢上皮癌中的高表达与肿瘤性质及发生发展相关,可能成为预测卵巢癌发生进展的新肿瘤标记物和治疗的靶点。
Objective To investigate the expression of phospholylate - mammalian target of rapamycin, p - roTOR, in epithelial ovarian cancer and its clinical significance. Methods The expression of p -mTOR was detected individually in the specimens of 154 epithelial ovarian cancer, 25 benign ovarian epithelia tumour, 34 normal ovarian tissues by immunohistochemistry. The correlation of p - roTOR expression to clinicopathologic feature of epithelial ovarian cancer was analyzed. Results The positive rate of p - roTOR in epithelial ovarian cancer was 53.90%. No expression was detected in benign ovarian epithelia tumour and normal ovarian tissues. The positive rate of p - roTOR in serous, mucinous, and endometriod ovarian adenocarcinoma were 54.78% , 58.33% , and 40% respectively （ P 〉 0. 05 ）. The positive rate of p - roTOR inⅠ/Ⅱ and Ⅲ/Ⅳ stage epithelial ovarian cancers tissues were 23.08% and 56.03% （P 〈 0. 05 ）. The positive rate of p - roTOR were 53.95% and 53.85% in high - moderately and poorly - differentiated epithelial ovarian cancers tissues （ P 〉 0. 05 ）. Conclusions The overexpression of p - roTOR is closely related to epithelial ovarian cancer initiation and progression. The p - mTOR may be served as a new tumor molecular marker and target for anticancer therapy.
出处
《辽宁医学院学报》
CAS
2011年第1期13-15,18,95,共5页
Journal of Liaoning Medical University (LNMU) Bimonthly
关键词
卵巢上皮癌
磷酸化的哺乳动物雷帕霉素靶蛋白
免疫组化
epithelial ovarian cancer
phosphorylate -mammalian target of rapamycin
immunohistochemistry
