摘要
目的探讨0.2Hz最大的刺激强度为2T磁刺激器0.2Hz 55%刺激强度下,连续刺激14 d后,观察帕金森大鼠黑质酪氨酸羟化酶(TH)阳性细胞和纤维的变化。方法利用6-OHDA制备帕金森大鼠模型,给予0.2Hz 55%刺激强度下rTMS连续14 d,然后用免疫组化ABC法检测黑质TH免疫阳性产物的变化。结果 rTMS作用后黑质致密部TH免疫阳性纤维标记物增多。结论 rTMS通过调节黑质致密部多巴胺神经元突触的变化产生治疗效应。
Objective To investigate the effect of 0.2Hz rTMS on tyrosine hydroxylase（TH） postive staining in the substantia nigra of Parkinson＇s disease model rats.Methods Hemiparkinson model rats were established by micro-injection of 6-hydroxydopamine（6-OHDA） into right dopaminergic neurons of substantia nigra.Fourteen successive stimulations were given,（0.2Hz 55% intensity of the total output 2T magnetic stimulator）,and TH positive neurons and fibers in substantia nigra were detected with immuno-histo-chemical method.Results Compared with that in the non-stimulation group,high TH positive fibers were iduced in substantia nigra.Conclusion The treatment effect of rTMS was because of affecting the synaotic transmission induced by dendritic remodeling.
出处
《公共卫生与预防医学》
2011年第1期5-8,共4页
Journal of Public Health and Preventive Medicine
