摘要
目的：探讨红细胞膜蛋白在红细胞变形性改变中的作用。方法：参照Ｌｅａｍｍｌｉ和Ｐｅａｃｏｃｋ方法，测定了肺心病Ⅰ型呼吸衰竭（Ⅰ组）１８例、Ⅱ型呼吸衰竭（Ⅱ组）１８例和健康对照（ＣＧ）２０例的红细胞膜带３蛋白、膜收缩蛋白二聚体（ＳｐＤ）和四聚体（ＳｐＴ）的相对含量与红细胞变形能力。结果：Ⅰ、Ⅱ组带３蛋白、ＳｐＤ、ＳｐＴ相对含量和红细胞变形指数（ＤＩ）与对照组均有显著差异，且肺心病病人的ＤＩ与带３蛋白相对含量呈显著正相关，与ＳｐＤ／ＳｐＴ比值呈显著负相关。结论：带３蛋白和膜收缩蛋白的异常，可能是导致肺心病人红细胞变形能力降低的重要因素之一。
Aim and Methods:To investigate the role of erythrocyte membrane protein in the
changes of erythrocyte deformability. The changes of erythrocyte deformability and band 3
protein and spectrin dimers(Sp D) and tetramers (Sp T) were studied in 18 cases of respiratory
fairlure type I (group I) and 18 cases of respiratory failure type II (group II) and 15 normal
subjects,using the methods of Chang,Liammli and peacock. Results: The erythrocyte
deformation index and relative content of band 3 protein and Sp T were significantly lower in
group I and II than that in CG . The relative content of Sp D and ratio of Sp D/Sp T were
signficanitly higher in group I and II than in CG. The erythrocyte deformability in group I and II
were positively related to the ratio of Sp D/Sp T. Conclusion: These findings suggested that the
abnormality of band 3 and spectrin may be one of the reasons that resulted in erythrocyte
deformability decrease in cor pulmonale patients with respiratory failure.
出处
《中国应用生理学杂志》
CAS
CSCD
1999年第2期173-175,共3页
Chinese Journal of Applied Physiology
关键词
红细胞
膜收缩蛋白
呼吸衰竭
红细胞变形
erythrocyte membrane
bands 3 protein
Spectrin
Respiratory failure
