摘要
采用兔自身对照交叉法,给予自制盐酸左氧氟沙星滴眼液,并以两种市售滴眼液作参比制剂,采用HPLC法测定给药后兔眼房水中的左氧氟沙星,自制盐酸左氧氟沙星滴眼液和两种参比制剂的主要药动学参数为:AUC_(0-∞)(5.10±0.46)、(2.48±0.32)和(4.74±0.10)μg·ml^(-1)·h,t_(1/2)(1.50±0.50)、(2.26±0.48)和(1.91±0.26)h,c_(max)(1.53±0.59)、(1.12±0.11)和(1.49±0.16)μg/ml。自制滴眼液与两种市售滴眼液的相对生物利用度为213.2%和110.4%。
According to a self-control crossover design,the self-made levofloxacin hydrochloride eye drops were administrated to rabbits with two brands of levofloxacin hydrochloride eye drops as the reference preparations. The concentrations of levofloxacin in the aqueous humor were determined by HPLC,and the main pharmacokinetic parameters were AUC_(0-∞)(5.10±0.46),(2.48±0.32) and(4.74±0.10)μg/ml·h,t_(1/2)(1.50±0.50),(2.26±0.48) and(1.91±0.26) h,c_(max)(1.53±0.59),(1.12±0.11) and(1.49±0.16)μg/ml.The relative bioavailability of self-made levofloxacin hydrochloride eye drops were 213.2%and 110.4%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第2期115-117,共3页
Chinese Journal of Pharmaceuticals
基金
天津市应用基础研究计划基金资助项目(07JCZDJC05200)