摘要
目的 观察N-三甲基壳聚糖（TMC）对药物初级制剂凝胶的透皮吸收促进作用.方法 以季铵化程度为60％的TMC（TMC60）为促渗剂,加入到甲氧沙林脂质体（LMOP）凝胶中或对LMOP进行包衣处理,再制备成凝胶.采用Franz扩散池,以不含促渗剂的LMOP凝胶为阴性对照,1％氮酮＋丙二醇为促渗剂的LMOP凝胶为阳性对照,考察游离TMC及TMC包衣对LMOP凝胶的体外透皮促进作用.结果 三种含促渗剂的LMOP凝胶与阴性对照相比,透皮效果及24h后皮肤蓄积量差异均有统计学意义（Х^2=8.65,P＜0.05）,且以游离的TMC60促渗作用最优.结论 TMC可促进LMOP凝胶的体外透皮吸收,值得进一步研究.
Objective To explore the enhancement effect of N-trimethyl chitosan（TMC） on transdermal absorption of 8-methoxypsoralen-loaded liposomal（LMOP） gels in vitro.Methods TMC with quaternization degree of 60% （TMC60） as the enhancer,the LMOP gels were prepared with free TMC60 or TMC60-coating.The enhancement of free TMC60 or TMC60-coating was studied by using Franz diffusion,cells with LMOP gels as the negative control and LMOP gels including 1% Azone ＋ propylene glycol as the positive control.Results Compared with the negative control,enhancement and drug amount in skin of LMOP gels with enhancer all showed significant difference （Х^2 =8.65,P 〈 0.05）,and the free TMC.60 was the best.Conclusion TMC can enhance the transdermal penetration of LMOP gels in vitro and is valuable to be studied further.
出处
《中国基层医药》
CAS
2013年第17期2587-2589,共3页
Chinese Journal of Primary Medicine and Pharmacy
