摘要
10头健康仔猪随机均分为健康组、脾虚组 ,按 2 0mg/kg的剂量进行内服左旋氧氟沙星的药动学研究。高效液相色谱法测定血浆中药物浓度 ,3P97药代动力学程序处理药时数据。健康组和脾虚组药动学数据适合一级吸收一室模型。健康组主要药动学数据为 :吸收半衰期 (t1 / 2ka)(0 42± 0 0 8)h ,消除半衰期 (t1 / 2ke) (7 62± 0 38)h ,达峰时间 (tmax) (1 85± 0 2 5)h ,达峰浓度 (Cmax) (6 99± 0 92 )mg/L ,药时曲线下面积 (AUC) (90 7± 1 0 0 7)mg·L- 1 ·h ,表观分布容积 (V/ F(s) ) (2 45± 0 2 8)L·kg,平均滞留时间 (MRT) (1 1 92± 0 94)h。脾虚组 :t1 / 2ka(1 1 7± 0 38)h ,t1 / 2ke (9 0 2± 1 1 8)h ,tmax (3 93± 1 0 5)h ,Cmax (4 2 8± 1 45)mg/L ,AUC (72 2 1± 1 6 0 7)mg·L- 1 ·h ,V/ F(s) (3 95±1 2 8)L·kg,MRT (1 3 74± 1 2 1 )h。结果表明
Ten healthy piglets are distributed into three groups in a average, randomly way, with five piglets in each group of the healthy group, spleen deficiency group. Pharmacokinetics were studied after a single oral administration of levofloxacin (20mg/kg) in piglets. The levofloxacin concentration in plasma was analysized with HPLC, pharmacokinetics PK parameters was calculated using 3P97 PK programe, and further pharmacokinetics analysis was performed using SPSS (12.0) statistic software. The datas of the drug concentration-time in the two groups of the healthy group, spleen deficiency group were fitted to a one- compartment model with first-order absorption. The main PK-Parameters of the healthy group were t_(1/2ka)(0.42±0.08)h,t_(1/2ke)(7.62±0.38)h,t_(max)(1.85±0.25)h,C_(max)(6.99±0.92)mg/L,AUC(90.7±10.07)mg·L^(-1)·h,V/_(F(s))(2.45±0.28)L·kg,MRT(11.92±0.94)h. The ones of the Spleen deficiency were t_(1/2ka)(1.17±0.38),t1/2ke(9.02±1.18)h,t_(max)(3.93±1.05)h,C_(max)(4.28±1.45)mg/L,AUC(72.21±16.07)mg·L^(-1)·h,V/_(F(s))(3.95±1.28)L·kg,MRT(13.74±1.21)h. The results indicated the spleen deficiency condition of the piglets influenced the PK of levofloxacin.
出处
《畜牧与兽医》
北大核心
2005年第1期18-20,共3页
Animal Husbandry & Veterinary Medicine
基金
四川省重点建设学科项目资助 (SZD0 4 1 8)
